Satoru Motoyama

TL;DR: A large body of knowledge already generated in this area supports the view that high-risk HPV types have the ability to transform cells into a malignant phenotype, but it remains unclear how and when cofactors or factors that are innate in the HPV-infected cells launch the host cells into an irreversible progression to carcinoma.

TL;DR: The results indicate that the features of BRCA-associated ovarian cancer in Japan appear to be similar to those in Western countries, and the L63X and Q934X mutations of B RCA1 seem to be common founder mutations unique to the Japanese population.

TL;DR: Analysis of clinical outcomes and therapeutic varieties in Japan from 1990 to 2003 showed that aggressive surgery including EH or RH at the time of initial operation offers the possibility of prolonged survival, and younger age, early stage, and surgical procedure were associated with significantly better OAS.

TL;DR: This innovative surgical procedure may be a potential alternative approach for the therapy of vaginal agenesis with the use of the absorbable adhesion barrier Interceed with excellent results.

TL;DR: To explore whether the candidate gene in this 3p22-p25 region contributed to carcinogenesis of familial ovarian cancer in a similar fashion to the tumor suppressor gene, it was observed that the frequency of LOH at four markers in this region was >50% only in tumor tissues from patients with no mutation in BRCA1 or BRC a2, not in those with a BRCa1 mutation.