Saul Suster

TL;DR: Sclerosing paraganglioma should be included in the differential diagnosis of sclerosing lesions of the head and neck region and mediastinum, and positive immunostaining for chromogranin, synaptophysin, and monoclonal neuron specific enolase is needed for establishing the correct diagnosis.

TL;DR: Four cases are presented of primary anterior mediastinal tumors in young adults that were characterized by solid, infiltrative lesions showing histologic and immunohistochemical features of rhabdomyoblastic differentiation, which are highly aggressive neoplasms that should be distinguished from germ cell, teratomatous, or carcinosarcomatous tumors with a focal rhabdomsarcoma component.

TL;DR: The close association of 16 cases of a distinctive variant of primary thymic epithelial neoplasm characterized by prominent spindling of the tumor cells suggests that some of these lesions may arise as a result of malignant transformation in a preexisting spindle cell thymoma.

TL;DR: The present review focuses principally on the various morphologic appearance that these tumors are able to adopt, the role of modern special techniques for diagnosis, and the conditions that need to be considered in their differential diagnosis.

TL;DR: Chordoma should be entertained in the differential diagnosis of posterior mediastinal tumors, and application of immunohistochemical stains or electron microscopy will be of aid in separating them from other conditions that may histologically closely resemble these lesions.