World Health Organization Classification of Tumours

MicroRNA (miRNA ) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein- coding genes involved in cancer.

MicroRNA signatures in human cancers

MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein- coding genes involved in cancer.

I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.

Oncomirs : microRNAs with a role in cancer

MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer

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Oncomirs — microRNAs with a role in cancer

Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part VII: excerpta V.

Hyalinizing Spindle Cell Tumors with Giant Rosette-like Structures

Hyalinizing spindle cell tumors with giant rosette-like structures. commentary

Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part XI: Excerpta IX.

Mediastinal teratomatous germ cell tumors with additional sarcomatous components are rare neoplasms. This report describes a 53-year-old man who had chest pain, dyspnea, and cough, and on further evaluation was found to have a large anterior mediastinal mass. Histologically, the tumor was complex and showed elements of mature teratoma admixed with the additional components of yolk sac tumor, angiosarcoma, and rhabdomyosarcoma. After surgical excision, the tumor was treated with 2 cycles of chemotherapy. Nine months after surgery, there is radiologic evidence of local recurrence. Mediastinal teratomas with additional germ cell and sarcomatous components are highly malignant neoplasms that require aggressive clinical intervention. Prompt recognition of these tumors by pathologists is important to warrant an appropriate therapeutic approach.

Mediastinal Teratoma With Additional Malignant Components: A Case With Prominent Angiosarcomatous Elements Admixed With Yolk Sac Tumor and Rhabdomyosarcoma

Saul Suster

Papers

Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part VII: excerpta V.

Hyalinizing Spindle Cell Tumors with Giant Rosette-like Structures

Hyalinizing spindle cell tumors with giant rosette-like structures. commentary

Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part XI: Excerpta IX.

Mediastinal Teratoma With Additional Malignant Components: A Case With Prominent Angiosarcomatous Elements Admixed With Yolk Sac Tumor and Rhabdomyosarcoma