Sawan Hurst

TL;DR: The technique effectively separates the moving and static scattering elements within tissue to achieve high resolution images of blood flow, mapped into the 3-D optically sectioned tissue beds, at speeds that allow for perfusion assessment in vivo.

TL;DR: Data suggest that endogenous FXI contributes to arterial thrombus propagation through a striking amplification of thrombin generation at the throm Bus luminal surface, supporting the concept that FXI blockade may offer therapeutic advantages over other antithrombotic agents in terms of bleeding complications.

TL;DR: It is shown that high quality imaging of cerebrovascular blood perfusion down to capillary level resolution with the intact skin and cranium are obtained in vivo with OMAG, without the interference from the blood perfusions in the overlaying skin.

TL;DR: Systemic anticoagulation by inhibitingFXI activation or FXIIa procoagulant activity during sepsis may limit the development of disseminated intravascular coagulation without increasing bleeding risks, and suggest that severe polymicrobial abdominal infection induces prothrombotic FXI activation, to the detriment of the host.

TL;DR: It is found thatFXI-deficient mice have reduced coagulopathy and increased survival relative to FXI-expressing wild-type mice during cecal ligation and puncture-induced acute peritonitis/sepsis and that pharmacologic inhibition of FXI activity may alter the course and outcome of some infections.