Scott E. Parnell

TL;DR: This study demonstrates that exposure to ethanol occurring in mice at stages corresponding to the human fourth week postfertilization results in structural brain abnormalities that are readily identifiable at fetal stages of development.

TL;DR: It is demonstrated that early prenatal ethanol exposure can cause more than one temporally-specific pattern of defects, and the need for an expansion of current diagnostic criteria is illustrated to better capture the full range of facial and brain dysmorphology in fetal alcohol spectrum disorders.

TL;DR: Gestational day 7 ethanol exposure resulted in a spectrum of median facial and forebrain deficiencies, as expected, which falls within the HPE spectrum; a spectrum for which facial dysmorphology is consistent with and typically is predictive of that of the forebrain.

TL;DR: It is shown that Coordinated analyses using human patients and animal models are likely to be highly fruitful in uncovering the genetics behind FASD, and potential mechanisms of reported gene-EtOH interactions are commented on.

TL;DR: A novel link between two distinct signaling pathways is established and has widespread implications for development, as well as diseases such as addiction and cancer.