Scott M. Rawls

TL;DR: The results suggest that the neuroprotective effects of memantine shown in cell culture studies are mediated in part through alternative novel mechanisms by reducing microglia-associated inflammation and by stimulating neurotrophic factor release from astroglia.

TL;DR: The results confirm the idea that CB(1) receptors mediate the hypothermic response to cannabinoid agonists and suggest that the POAH is the central locus for thermoregulation, and CB( 1) receptors within thePOAH are the primary mediators of cannabinoid-induced hypothermia.

TL;DR: The CPP and dopamine-sensitive motor activation produced by me phedrone is suggestive of abuse liability and indicates commonalities between the neuropharmacological profiles of mephedrone and established drugs of abuse.

TL;DR: The results suggest that repeated MEPH exposure produces preferential sensitization to repetitive movement produced by acute MEPH challenge, suggesting that MEPH is a unique stimulant displaying weak sensitizing properties with overlapping, but distinctive, features relative to established psychostimulant drugs.

TL;DR: The most commonly abused synthetic cathinone in the UK is 4-Methylmethcathinone (mephedrone, MEPH) as discussed by the authors, which exerts its effects by acting as a substrate-type releaser at monoamine transporters.