Showing papers by "Scott Wilhelm published in 2000"

TL;DR: Optimization for cellular potency led to the discovery of a new class of potent and selective p38 kinase inhibitors, exemplified by the 1-phenyl-5-pyrazolyl urea 7 (IC50 = 13 nM).

TL;DR: Novel small-molecule inhibitors of p38 kinase were derived from a combinatorial chemistry effort and exhibit activity in the nanomolar range, and very steep structure-activity relationships are observed within this class.