S
Sean J. Colloby
Researcher at Newcastle University
Publications - 88
Citations - 3794
Sean J. Colloby is an academic researcher from Newcastle University. The author has contributed to research in topics: Dementia with Lewy bodies & Dementia. The author has an hindex of 31, co-authored 83 publications receiving 3168 citations. Previous affiliations of Sean J. Colloby include Barts Health NHS Trust.
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Journal ArticleDOI
Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies.
John T. O'Brien,Sean J. Colloby,John D. Fenwick,E. David Williams,Michael J. Firbank,David J. Burn,Dag Aarsland,Ian G. McKeith +7 more
TL;DR: Dopamine transporter loss can be detected in vivo using FP-CIT SPECT in DLB and both region of interest analysis and visual ratings provided good separation between DLBs and AD.
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A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping.
Sean J. Colloby,John D. Fenwick,David E. Williams,SM Paling,Kyriakos Lobotesis,Clive Ballard,Ian G. McKeith,John T. O'Brien +7 more
TL;DR: Evidence of frontal and parietal hypoperfusion in both AD and DLB is found, while temporal perfusion deficits were observed exclusively in AD and parieto-occipital deficits in DLB.
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Parietal white matter lesions in Alzheimer’s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease
Kirsty E. McAleese,Lauren Walker,Sophie Graham,Elisa L. J. Moya,Mary Johnson,Daniel Erskine,Sean J. Colloby,Madhurima Dey,Carmen Martin-Ruiz,John-Paul Taylor,Alan J. Thomas,Ian G. McKeith,Charles De Carli,Johannes Attems +13 more
TL;DR: Parietal W ML as seen on MRI should not invariably be interpreted as a surrogate biomarker for SVD as they may be indicative of cortical AD-pathology, and therefore, AD should also be considered as the main underlying cause for cognitive impairment in cases with parietal WML.
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Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes
Lauren Walker,Kirsty E. McAleese,Alan J. Thomas,Mary Johnson,Carmen Martin-Ruiz,Craig Parker,Sean J. Colloby,Kurt A. Jellinger,Johannes Attems +8 more
TL;DR: It is shown that in neuropathologically mixed AD/DLB cases both the amount and the topographical distribution of pathological protein aggregates differed between distinct clinical phenotypes.
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Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias.
TL;DR: Results suggest that reduced uptake in vivo may be influenced considerably by neuronal loss rather than the presence of pathological lesions, in particular those related to Alzheimer's disease and Lewy body dementias.