Sebastiao Tostes

TL;DR: These studies demonstrate that T. cruzi, or a portion of its genome, is present in the inflammatory lesion of chronic cardiac Chagas' disease.

TL;DR: The inflammatory infiltrates in the heart lesions of chronic chagasic cardiomyopathy are composed predominantly of small lymphocytes with admixed macrophages, plasma cells, and segmented leukocytes, and the phenotypes of the lymphoid cells in these infiltrates have not been previously detailed.

TL;DR: Success using the LSSP-PCR technique in profiling the T. cruzi parasites present in the hearts of 13 patients with chagasic cardiopathy and in the esophagi of four patients is reported, suggesting that the genetic variability of the parasite is one of the determining factors of the clinical form of the disease.

TL;DR: In this article, a low-stringency single specific primer PCR (LSSP-PCR) was applied to the study of the variable region of kinetoplast DNA minicircles from T cruzi.

TL;DR: Comparative immunohistochemical analyses show that HLA-ABC antigen expression is enhanced on the myocardial cells of chagasic patients with chronic cardiomyopathy, suggesting a possible role for these cells as targets for the CD8+ cytolytic lymphocytes dominant in these lesions.