S
Seiichi Kobayashi
Researcher at Eisai
Publications - 45
Citations - 1201
Seiichi Kobayashi is an academic researcher from Eisai. The author has contributed to research in topics: Retinoic acid receptor & Agonist. The author has an hindex of 15, co-authored 45 publications receiving 1159 citations.
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Journal ArticleDOI
Inhibition of Endotoxin Response by E5564, a Novel Toll-Like Receptor 4-Directed Endotoxin Antagonist
Maureen A. Mullarkey,Jeffrey Rose,J R Bristol,Tsutomu Kawata,Akufumi Kimura,Seiichi Kobayashi,Melinda Przetak,Jesse Chow,Fabian Gusovsky,William J. Christ,Daniel P. Rossignol +10 more
TL;DR: Results indicate that E5564 is a potent antagonist of LPS and lacks agonistic activity in human and animal model systems, making it a potentially effective therapeutic agent for treatment of disease states caused by endotoxin.
Journal ArticleDOI
2-Alkynyl-8-aryl-9-methyladenines as Novel Adenosine Receptor Antagonists: Their Synthesis and Structure−Activity Relationships toward Hepatic Glucose Production Induced via Agonism of the A2B Receptor
Hitoshi Harada,Osamu Asano,Yorihisa Hoshino,Seiji Yoshikawa,Masayuki Matsukura,Yasuhiro Kabasawa,Jun Niijima,Yoshihiko Kotake,Nobuhisa Watanabe,Tsutomu Kawata,Takashi Inoue,Tatsuo Horizoe,Nobuyuki Yasuda,Hiroe Minami,Kaya Nagata,Manabu Murakami,Junsaku Nagaoka,Seiichi Kobayashi,Isao Tanaka,Shinya Abe +19 more
TL;DR: The results suggest that adenosine agonist-induced glucose production in rat hepatocytes is mediated through the A(2B) receptor, and further elaboration of this group of compounds may afford novel antidiabetic agents.
Patent
Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes
Osamu Asano,Hitoshi Harada,Yorihisa Hoshino,Seiji Yoshikawa,Takashi Inoue,Tatsuo Horizoe,Nobuyuki Yasuda,Kaya Nagata,Junsaku Nagaoka,Manabu Murakami,Seiichi Kobayashi +10 more
TL;DR: In this article, a novel type for diabetes and complications thereof based on the adenosine A2 receptor antagonism was proposed, which is useful in preventing and treating diabetes and its complications.
Journal ArticleDOI
Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones.
Hironori Ikuta,Hiroshi Shirota,Seiichi Kobayashi,Y. Yamagishi,Koji Yamada,Isao Yamatsu,K. Katayama +6 more
TL;DR: One of the compounds, N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-o ne, was found to have a wider safety margin than indomethacin or piroxicam, and was selected for detailed evaluation as a candidate drug for clinical application.
Journal ArticleDOI
Functional characterization of the adenosine receptor contributing to glycogenolysis and gluconeogenesis in rat hepatocytes
Nobuyuki Yasuda,Takashi Inoue,Tatsuo Horizoe,Kaya Nagata,Hiroe Minami,Tsutomu Kawata,Yorihisa Hoshino,Hitoshi Harada,Seiji Yoshikawa,Osamu Asano,Junsaku Nagaoka,Manabu Murakami,Shinya Abe,Seiichi Kobayashi,Isao Tanaka +14 more
TL;DR: It is suggested thatadenosine stimulates cyclic AMP formation and regulates glycogenolysis and gluconeogenesis, most likely through the adenosine A(2B) receptor subtype in rat hepatocytes.