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William J. Christ
Researcher at Eisai
Publications - 40
Citations - 3951
William J. Christ is an academic researcher from Eisai. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 23, co-authored 40 publications receiving 3815 citations. Previous affiliations of William J. Christ include Massachusetts Institute of Technology & Harvard University.
Papers
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Journal ArticleDOI
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction *
TL;DR: It is demonstrated that TLR4 is involved in lipopolysaccharide signaling and serves as a cell-surface co-receptor for CD14, leading to lipopoly Saccharide-mediated NF-κB activation and subsequent cellular events.
Journal ArticleDOI
Catalytic effect of nickel(II) chloride and palladium(II) acetate on chromium(II)-mediated coupling reaction of iodo olefins with aldehydes
Journal ArticleDOI
Inhibition of Endotoxin Response by E5564, a Novel Toll-Like Receptor 4-Directed Endotoxin Antagonist
Maureen A. Mullarkey,Jeffrey Rose,J R Bristol,Tsutomu Kawata,Akufumi Kimura,Seiichi Kobayashi,Melinda Przetak,Jesse Chow,Fabian Gusovsky,William J. Christ,Daniel P. Rossignol +10 more
TL;DR: Results indicate that E5564 is a potent antagonist of LPS and lacks agonistic activity in human and animal model systems, making it a potentially effective therapeutic agent for treatment of disease states caused by endotoxin.
PatentDOI
Automated oligosaccharide synthesizer
TL;DR: This tutorial review defines the state of the art of automated solid phase oligosaccharide synthesis and identifies areas in need of further innovation.
Journal Article
CD11/CD18 and CD14 Share a Common Lipid A Signaling Pathway
Robin R. Ingalls,Brian G. Monks,R Savedra,William J. Christ,Russell L. Delude,Andrei E. Medvedev,Terje Espevik,Douglas T. Golenbock +7 more
TL;DR: It is proposed that this receptor, which is the target of the LPS antagonists, functions as the true signal transducer in LPS-induced cellular activation for both CD14 and CD11/CD18.