S
Seiler N
Researcher at Centre national de la recherche scientifique
Publications - 8
Citations - 166
Seiler N is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Polyamine & Ornithine decarboxylase. The author has an hindex of 7, co-authored 8 publications receiving 159 citations.
Papers
More filters
Journal Article
Polyamine deprivation enhances antitumoral efficacy of chemotherapy.
TL;DR: It is demonstrated that a significant enhancement of the efficacy of chemotherapy was achieved without concomitant enhancement of toxic effects.
Journal Article
Inhibition of the growth of U-251 human glioblastoma in nude mice by polyamine deprivation.
TL;DR: An almost complete prevention of tumor growth was achieved in U-251 human glioblastoma xenografted nude mice by partial decontamination of the gastrointestinal tract and feeding of a polyamine-free diet containing inhibitors of ornithine decarboxylase and of polyamine oxidase.
Journal ArticleDOI
(Z)-1,4-diamino-2-butene as a vector of boron, fluorine, or iodine for cancer therapy and imaging: synthesis and biological evaluation.
Bénédicte Martin,Francoise Posseme,Caroline Le Barbier,François Carreaux,Bertrand Carboni,Seiler N,Jacques-Philippe Moulinoux,Jean-Guy Delcros +7 more
TL;DR: In the present work, the synthesis and characterization of new derivatives of Z-DAB were reported and its potential in BNCT will be evaluated.
Journal Article
Bis(7-amino-4-azaheptyl)dimethylsilane: a new tetramine with polyamine-like features. Effects on cell growth.
TL;DR: Depletion of intracellular spermidine together with binding to functionally important polyamine binding sites are considered the main features of the compound which cause cytostatic, and at high concentrations, cytotoxic effects.
Journal ArticleDOI
Characterization of amine oxidase activities in macrophages from human peripheral blood.
TL;DR: Since the formation of toxic products by a releasable polyamine oxidase is supposed to be an integral part of a regulatory function of macrophages, this work is considered as a basis for the elucidation of this function.