H
Havouis R
Researcher at University of Rennes
Publications - 18
Citations - 431
Havouis R is an academic researcher from University of Rennes. The author has contributed to research in topics: Polyamine & Spermidine. The author has an hindex of 11, co-authored 18 publications receiving 414 citations.
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Journal ArticleDOI
Polyamine deficient diet to relieve pain hypersensitivity.
Cyril Rivat,Philippe Richebé,Emilie Laboureyras,Jean Paul Laulin,Havouis R,Florence Noble,J.-P. Moulinoux,Guy Simonnet +7 more
TL;DR: A polyamine deficient diet (PD diet) for 7 days prevented the enhancement of tyrosine phosphorylation of the spinal NR2B subunit‐containing NMDA‐R associated with inflammation in rats and reversed pain hypersensitivity associated with monoarthritis or neuropathy and restored the analgesic effect of morphine.
Journal Article
Polyamine deprivation enhances antitumoral efficacy of chemotherapy.
TL;DR: It is demonstrated that a significant enhancement of the efficacy of chemotherapy was achieved without concomitant enhancement of toxic effects.
Journal Article
Inhibition of the growth of U-251 human glioblastoma in nude mice by polyamine deprivation.
TL;DR: An almost complete prevention of tumor growth was achieved in U-251 human glioblastoma xenografted nude mice by partial decontamination of the gastrointestinal tract and feeding of a polyamine-free diet containing inhibitors of ornithine decarboxylase and of polyamine oxidase.
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The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox.
Karine Chantrel-Groussard,François Gaboriau,N. Pasdeloup,Havouis R,Hanspeter Nick,Jean-Louis Pierre,Pierre Brissot,Gérard Lescoat +7 more
TL;DR: It is suggested that ICL670A has the most efficient antitumoral effect, blocks cell proliferation by a pathway different of O-trensox and may constitute a potential drug for anticancer therapy.
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Atmospheric pressure chemical ionization-mass spectrometry method to improve the determination of dansylated polyamines.
TL;DR: It is shown that atmospheric pressure chemical ionization-mass spectrometry (MS) can be used to detect and quantify biologically relevant polyamines after dansylation, without chromatographic separation.