Showing papers by "Senthamaraikannan Kabilan published in 2010"
TL;DR: QSAR study indicated that the increase in weakly polar component of solvent accessible surface area will favour antibacterial activity while increase in polarizability and decrease in ionisation potential and hydrogen bond donor will favour antifungal activity.
34 citations
TL;DR: All the synthesized oximes and oxime ethers were evaluated for their in vitro antimicrobial activity against a panel of pathogenic bacteria and fungi, and as a result of the structure-activity correlations, some lead molecules were known for further optimization.
28 citations
TL;DR: In this paper, the synthesis of p -phenylenediamine ( p -PDA)-aniline copolymer was carried out using K 2 S 2 O 8 and (NH 4 ) 2 S O 8 as an oxidizing agent and the newly synthesized copolymers was characterized by UV-visible, FT-IR, fluorescence, proton NMR, cyclic voltammetry, solubility and SEM studies.
27 citations
TL;DR: The microbiological analysis showed that the electron withdrawing function substituted phenyl group at C-2 and C-4 of azabicyclononane based thiadiazoles 4c/4h and 5c/5h exposed significant antimicrobial activity against Salmonella typhi, Escherichia coli, Klebsiella pneumoniae, Aspergillus flavus, As pergillus niger and Candida albicans.
14 citations
TL;DR: In this article, a series of thiosemicarbazones and semicarazones have been synthesized and characterized by one and two dimensional NMR spectroscopy.
9 citations
TL;DR: In this article, a cyclization of 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-yl]-5-spiro-4-acetyl-2-(acetylamino)-Δ2-1, 3, 4-thiadiazoline derivatives (3a-h) have been synthesized by the cyclization.
8 citations
TL;DR: Two series of bicyclic oxime ethers viz, 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one O-benzyloximes 13-24 and 2, 4,6,8-tetraaryl-3,7-diazabicycleclo [3.2.3] nonan-nine-one oxime oximes 31-36 were synthesized and stereochemistry was established by their spectral (1D and 2D NMR) and crystal
Abstract: Two series of bicyclic oxime ethers viz, 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one O-benzyloximes 13-24 and 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-one O-benzyloximes 31-36 were synthesized and stereochemistry was established by their spectral (1D and 2D NMR) and crystal studies. Synthesized oxime ethers were screened for their in vitro antimicrobial activity against a set of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans, Candida-51, Rhizopus sp., Aspergillus niger and Aspergillus flavus) by twofold serial dilution method, respectively, using Ciprofloxacin and Amphotericin B as standards. Most of the molecules expressed promising antimicrobial profile against the tested pathogens and even a few compounds 16, 21, 22, 33 and 34 were better than standard drugs.
6 citations
1 citations
TL;DR: Two closely related oximes, namely 1-chloroacetyl-3-ethyl-2,6-diphenylpiperidin-4-one oxime, C(21)H(23)ClN(2)O(2), (I) and (II), despite their identical sets of hydrogen-bond donors and acceptors, display basically different hydrogen- bonding patterns in their crystal structures.
Abstract: Two closely related oximes, namely 1-chloroacetyl-3-ethyl-2,6-diphenylpiperidin-4-one oxime, C(21)H(23)ClN(2)O(2), (I), and 1-chloroacetyl-2,6-diphenyl-3-(propan-2-yl)piperidin-4-one oxime, C(22)H(25)ClN(2)O(2), (II), despite their identical sets of hydrogen-bond donors and acceptors, display basically different hydrogen-bonding patterns in their crystal structures. While the molecules of (I) are organized into typical centrosymmetric dimers, created by oxime-oxime O-H center dot center dot center dot N hydrogen bonds, in the structure of (II) there are infinite chains of molecules connected by O-H center dot center dot center dot O hydrogen bonds, in which the carbonyl O atom from the chloroacetyl group acts as the hydrogen-bond acceptor. Despite the differences in the hydrogen-bond schemes, the -OH groups are always in typical anti positions (C-N-O-H torsion angles of ca 180 degrees). The oxime group in (I) is disordered, with the hydroxy groups occupying two distinct positions and C-C-N-O torsion angles of approximately 0 and 180 degrees for the two alternatives. This disorder, even though the site-occupancy factor of the less occupied position is as low as ca 0.06, is also observed at lower temperatures, which seems to favour the statistical and not the dynamic nature of this phenomenon.
1 citations
TL;DR: The piperidin-4-one ring adopts a boat conformation as mentioned in this paper, making a dihedral angle of 74.07 (8)°, which is the largest known dihedral angles for a piperidean compound.
Abstract: In the title compound, C21H20Cl3NO2, the piperidin-4-one ring adopts a boat conformation. The two 2-chlorophenyl groups are approximately perpendicular to each other, making a dihedral angle of 74.07 (8)°.
TL;DR: In the title compound, C20H21F2NO, the piperidine ring in each of the two independent molecules in the asymmetric unit adopts a normal chair conformation with an equatorial orientation of the 3-fluorophenyl groups.
Abstract: In the title compound, C20H21F2NO, the piperidine ring in each of the two independent molecules in the asymmetric unit adopts a normal chair conformation with an equatorial orientation of the 3-fluorophenyl groups. The dihedral angles between the two 3-fluorophenyl rings are 49.89 (7) and 50.35 (7)° in the two molecules.
TL;DR: In the title compound, C21H20Cl3NO2, the piperidin-4-one ring adopts a boat conformation, and the two 2-chlorophenyl groups are approximately perpendicular to each other, making a dihedral angle of 74.07 (8)°.
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