Serge Halimi

TL;DR: Results show that a high fructose diet in rats leads to insulin resistance and a defect in the free radical defense system, and vitamin E supplementation improves insulin sensitivity in fructose-fed rats.

TL;DR: The TG-to-HDL cholesterol ratio may be related to the processes involved in LDL size pathophysiology and relevant with regard to the risk of clinical vascular disease and suitable for the selection of patients needing an earlier and aggressive treatment of lipid abnormalities.

TL;DR: Zinc deficiency in insulin-dependent diabetic patients is corrected by a zinc supplementation that decreases lipid peroxidation and could be linked to the protective effect of zinc on the protein itself.

TL;DR: In this paper, the authors provided the fundamental background of the inflammation theory associated with type 2 diabetes, and discussed the clinical consequences of low-grade inflammation, particularly in terms of cardiovascular risk, and to infer some clinical therapeutic strategies deriving from drugs that already exist or are in development.

TL;DR: Adenovirus-mediated catalase gene transfer is validated as a realistic approach to reduce non specific inflammation effects on human or porcine islet grafts.