Showing papers by "Serge L. Beaucage published in 1981"
TL;DR: In this article, the development of a new class of nucleoside phosphites is described, which are stable to normal laboratory conditions, are activated by mild acid treatment, and are observed to react essentially quantitatively with protected nucleosides.
2,299 citations
Patent•
27 Mar 1981
TL;DR: A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature was introduced in this paper.The phosphoramide is a derivatives of saturated secondary amines.
Abstract: A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.
561 citations