S
Sergey N. Kochetkov
Researcher at Engelhardt Institute of Molecular Biology
Publications - 240
Citations - 3555
Sergey N. Kochetkov is an academic researcher from Engelhardt Institute of Molecular Biology. The author has contributed to research in topics: Reverse transcriptase & Polymerase. The author has an hindex of 22, co-authored 212 publications receiving 2929 citations. Previous affiliations of Sergey N. Kochetkov include Russian State Geological Prospecting University & Russian Academy of Sciences.
Papers
More filters
Journal ArticleDOI
Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1.
Olga A. Smirnova,Olga N. Ivanova,Birke Bartosch,Vladimir T. Valuev-Elliston,Furkat Mukhtarov,Sergey N. Kochetkov,Alexander V. Ivanov +6 more
TL;DR: The data show that NS5A protein induces oxidative stress by several multistep mechanisms and contributes to ROS production by activating expression of NADPH oxidases 1 and 4 as well as cytochrome P450 2E1.
Journal ArticleDOI
Redox Biology of Respiratory Viral Infections.
TL;DR: Changes in redox homeostasis in infected cells are one of the key events that is linked to infection with respiratory viruses and linked to inflammation and subsequent tissue damage.
Journal ArticleDOI
Oxidative Stress during HIV Infection: Mechanisms and Consequences
Alexander V. Ivanov,Vladimir T. Valuev-Elliston,Olga N. Ivanova,Sergey N. Kochetkov,Elizaveta Starodubova,Birke Bartosch,Maria G. Isaguliants +6 more
TL;DR: Current state of knowledge on the redox alterations as crucial factors of HIV-1 pathogenicity, such as neurotoxicity and dementia, exhaustion of CD4+/CD8+ T-cells, predisposition to lung infections, and certain side effects of the antiretroviral therapy are presented and compared to the pathologies associated with the nitrosative stress.
Journal ArticleDOI
HCV and Oxidative Stress in the Liver
Alexander V. Ivanov,Birke Bartosch,Olga A. Smirnova,Maria G. Isaguliants,Sergey N. Kochetkov +4 more
TL;DR: The search for ROS sources in HCV-infected cells revealed several mechanisms of ROS production and thus a number of cellular proteins have become targets for future studies, and it is shown that HCV modifies antioxidant defense mechanisms.
Journal ArticleDOI
Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 Cells
Alexander V. Ivanov,Olga A. Smirnova,Olga A. Smirnova,Olga N. Ivanova,O. V. Masalova,Sergey N. Kochetkov,Maria G. Isaguliants +6 more
TL;DR: It is shown that HCV proteins core, E1, E2, NS4B, and NS5A activate antioxidant defense Nrf2/ARE pathway via several independent mechanisms, which induced a strong up-regulation of the antioxidant defense system on the earliest stage of expression.