S
Sergio Duarte
Researcher at University of California, Los Angeles
Publications - 30
Citations - 903
Sergio Duarte is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Reperfusion injury & Transplantation. The author has an hindex of 12, co-authored 25 publications receiving 731 citations. Previous affiliations of Sergio Duarte include University of Porto & University of Florida.
Papers
More filters
Journal ArticleDOI
Matrix metalloproteinases in liver injury, repair and fibrosis.
TL;DR: Some of the MMP-attributed roles in acute and chronic liver injury are highlighted and the need for further experimentation is emphasized to better understand their functions during hepatic physiological conditions and disease progression.
Journal ArticleDOI
Inducible Nitric Oxide Synthase Deficiency Impairs Matrix Metalloproteinase-9 Activity and Disrupts Leukocyte Migration in Hepatic Ischemia/Reperfusion Injury
TL;DR: Evidence is provided for a novel mechanism by which MMP-9 can mediate iNOS-induced liver I/R injury and lead to detachment of hepatocytes from the extracellular matrix and cell death, in addition to regulating leukocyte migration across extracllular matrix barriers.
Journal ArticleDOI
Cyclooxygenase-2 Deficiency Enhances Th2 Immune Responses and Impairs Neutrophil Recruitment in Hepatic Ischemia/Reperfusion Injury
Takashi Hamada,Sei-ichiro Tsuchihashi,Armine Avanesyan,Sergio Duarte,Carolina Moore,Ronald W. Busuttil,Ana J. Coito +6 more
TL;DR: The data support the concept that COX-2 is involved in the pathogenic events occurring in liver ischemia/reperfusion (I/R) injury, and suggest that potential valuable therapeutic approaches in liver I/R injury may result from further studies aimed at identifying specific COx-2-derived prostanoid pathways.
Journal ArticleDOI
Is there a plastid in Perkinsus atlanticus (Phylum Perkinsozoa)
M. Leonor Teles-Grilo,Joana Tato-Costa,Sergio Duarte,Alexandre Maia,Graça Casal,Carlos Azevedo +5 more
TL;DR: Molecular analysis of some conserved nuclear genes shows a closer proximity of the genus Perkinsus to the dinoflagellates than to the apicomplexans, and this work identifies a plastid in Perkinsus atlanticus, using ultrastructural techniques and inhibition growth tests.
Journal ArticleDOI
MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury
Hiroyuki Kato,Naohisa Kuriyama,Sergio Duarte,Pierre-Alain Clavien,Ronald W. Busuttil,Ana J. Coito +5 more
TL;DR: In vitro approaches show that targeted inhibition of MMP-9 sheltered the extracellular portion of PECAM-1 from proteolytic processing, and disrupted leukocyte migration across this junctional molecule and disrupts vascular integrity at least partially through a PECam-1 dependent mechanism and interferes with regeneration of steatotic livers after IRI.