Sergio G. Coutinho

TL;DR: Results indicate that macrophage interactions with dead neutrophils play a previously unrecognized role in host responses to L. major infection, and parasite killing depended on neutrophil elastase and TNF-α production.

TL;DR: Data from a prospective study are consistent with a major role of polyclonal B cell activation in the induction of IC during visceral leishmaniasis.

TL;DR: Patients suffering from American cutaneous leishmaniasis showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ Blast T cells in cultures and the levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured.

TL;DR: The observed T-cell responses maintained for a long period in healed patients could be relevant for immunoprotection against reinfection and used as a parameter for determining the prognosis of patients and selecting future vaccine preparations.

TL;DR: Two former patients treated for the cutaneous form of American tegumentary leishmaniasis were reviewed eight and 11 years, respectively, following clinical cure, and the histopathology revealed discreet hyperceratosis and a slight infiltrate of mononuclear cells surrounding and on the walls of the surface and deep dermal vessels.