Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.
TLDR
Patients suffering from American cutaneous leishmaniasis showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ Blast T cells in cultures and the levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured.Abstract:
Fourteen patients suffering from American cutaneous leishmaniasis were studied. Assays of the lymphocyte proliferative response induced in vitro by Leishmania braziliensis antigens were performed. After 5 days in culture, L. braziliensis-stimulated blast T cells were harvested for CD4+ and CD8+ phenotype analysis. When results before and at the end of therapy were compared, leishmaniasis patients showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ blast T cells in cultures. The levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured. These results show a pattern of higher proportions of Leishmania-reactive CD8+ T cells and lower proportions of Leishmania-reactive CD4+ T cells after cure.read more
Citations
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The immunology of susceptibility and resistance to Leishmania major in mice
TL;DR: Established models of T-helper-2-cell dominance in BALB/c mice infected with Leishmania major — involving the early production of interleukin-4 by a small subset of LeishMania-specific CD4+ T cells — have been refined by accumulating evidence that this response is not sufficient and, under some circumstances, not required to promote susceptibility.
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Leishmania and human immunodeficiency virus coinfection: the first 10 years.
Jorge Alvar,Carmen Cañavate,Beatriz Gutiérrez-Solar,Maribel Jiménez,Fernando Laguna,Rogelio López-Vélez,Ricardo Molina,Javier Moreno +7 more
TL;DR: Over 850 Leishmania-human immunodeficiency virus (HIV) coinfection cases have been recorded, the majority in Europe, where 7 to 17% of HIV-positive individuals with fever have amastigotes, suggesting that Leishmanniasis-infected individuals without symptoms will express symptoms of leishmaniasis if they become immunosuppressed.
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Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate.
Gustavo Adolfo Sierra Romero,Marcus Vinitius de Farias Guerra,Marcilene Gomes Paes,Vanize Macêdo +3 more
TL;DR: It is concluded that Leishmania species constitute an important factor in predicting the outcome of cutaneous leishmaniasis treated with a pentavalent antimonial and remained significant after adjusting for age, disease duration, and site and number of lesions that were identified as predictors of failure in a logistic regression model.
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Immunobiology of visceral leishmaniasis
Rajiv Kumar,Susanne Nylén +1 more
TL;DR: In this review, immunological events described in human and experimental VL and how these can affect the outcome of infection are discussed.
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Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis.
Lis Ribeiro do Valle Antonelli,Walderez O. Dutra,Roque P. Almeida,Olívia Bacellar,Edgar M. Carvalho,Kenneth J. Gollob +5 more
TL;DR: It is demonstrated that immunological markers are correlated with clinical indicators of human leishmaniasis and serve to better understand the evolution of this important parasitic disease.
References
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Journal Article
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Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets.
TL;DR: The data are consistent with the expansion of type 1 helper cells during healing and type 2 helper cells (Th2) during progressive leishmania infection.