S
Sergio Villordo
Researcher at Fundación Instituto Leloir
Publications - 14
Citations - 1059
Sergio Villordo is an academic researcher from Fundación Instituto Leloir. The author has contributed to research in topics: RNA & Viral replication. The author has an hindex of 12, co-authored 14 publications receiving 892 citations.
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Genome cyclization as strategy for flavivirus RNA replication
TL;DR: The latest information about cis-acting elements involved in flavivirus genome cyclization, RNA promoter elements required for viral polymerase recognition, and how these elements together coordinate viral RNA synthesis are described.
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RNA Structure Duplications and Flavivirus Host Adaptation
TL;DR: New hypotheses of how these RNA elements specialize for replication in vertebrate and invertebrate hosts are discussed, and new ideas associating the significance of RNA structure duplication, small subgenomic flavivirus RNA formation, and host adaptation are presented.
Journal ArticleDOI
Dengue Virus RNA Structure Specialization Facilitates Host Adaptation
Sergio Villordo,Claudia Veronica Filomatori,Irma Sanchez-Vargas,Carol D. Blair,Andrea V. Gamarnik +4 more
TL;DR: New concepts in adaptation of RNA viruses are revealed, in which host specialization of RNA structures results in high fitness in the adapted host, while RNA duplication confers robustness during host switching.
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A balance between circular and linear forms of the dengue virus genome is crucial for viral replication
TL;DR: A model in which the viral genome exists in at least two alternative conformations and the balance between these two states is critical for infectivity is proposed, suggesting the need of a linear conformation of the genome.
Journal ArticleDOI
RNA Sequences and Structures Required for the Recruitment and Activity of the Dengue Virus Polymerase
Claudia Veronica Filomatori,Nestor Gabriel Iglesias,Sergio Villordo,Diego E. Alvarez,Andrea V. Gamarnik +4 more
TL;DR: It is proposed that the long range RNA-RNA interactions in the viral genome play multiple roles during RNA synthesis, and new molecular details about the promoter-dependent dengue virus RNA polymerase activity are provided.