S
Sergiu P. Pașca
Researcher at Stanford University
Publications - 22
Citations - 2291
Sergiu P. Pașca is an academic researcher from Stanford University. The author has contributed to research in topics: Induced pluripotent stem cell & Forebrain. The author has an hindex of 12, co-authored 22 publications receiving 1094 citations.
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Journal ArticleDOI
The rise of three-dimensional human brain cultures
TL;DR: How this approach can be used to understand unique features of the human brain and to gain insights into neuropsychiatric disorders is discussed.
Journal ArticleDOI
Reliability of human cortical organoid generation.
Se-Jin Yoon,Lubayna S. Elahi,Anca M. Pașca,Rebecca M. Marton,Aaron Gordon,Omer Revah,Yuki Miura,Elisabeth M. Walczak,Gwendolyn M. Holdgate,H. Christina Fan,John R. Huguenard,Daniel H. Geschwind,Sergiu P. Pașca +12 more
TL;DR: A protocol adapted to xeno- and feeder-free conditions is shown to generate reliable and consistent cortical brain organoids across differentiations and source stem cell lines, making it suitable for disease modeling and other applications.
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Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures.
Rebecca M. Marton,Yuki Miura,Steven A. Sloan,Qingyun Li,Omer Revah,Rebecca J. Levy,John R. Huguenard,Sergiu P. Pașca +7 more
TL;DR: A new differentiation method of human induced pluripotent stem cells is developed to generate three-dimensional brain organoids that contain oligodendrocytes as well as neurons and astroCytes, called human oligodendedrocyte spheroids, which are transcriptionally similar to primary cells and mature to myelinate axons.
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Generation and assembly of human brain region–specific three-dimensional cultures
TL;DR: This protocol describes how to generate and assemble subdomain-specific forebrain spheroids, also known as brain region–specific organoids, from human pluripotent stem cells (hPSCs), and combines them in vitro to assemble forebrain assembloids that recapitulate the interactions of glutamatergic and GABAergic neurons seen in vivo.
Journal ArticleDOI
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.
Yuki Miura,Min-Yin Li,Fikri Birey,Kazuya Ikeda,Omer Revah,Mayuri Vijay Thete,Jin-Young Park,Alyssa Puno,Samuel H. Lee,Matthew H. Porteus,Sergiu P. Pașca +10 more
TL;DR: A method to convert human pluripotent stem cells into region-specific brain organoids that resemble the developing human striatum and include electrically active medium spiny neurons is developed, showing that cortical neurons send axonal projections into striatal organoids and form synaptic connections.