Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species

Five new α-tetralonyl glucosides, juglanosides A—E (1—5) were isolated from the fresh rejuvenated fruit of Juglans mandshurica. Their structures were elucidated as (4S)-4-hydroxy-α-tetralone 4-O-β-D-glucopyranoside (1), (4S)-4,5-dihydroxy-α-tetralone 4-O-β-D-glucopyranoside (2), (4S)-4,6-dihydroxy-α-tetralone 4-O-β-D-glucopyranoside (3), (4S)-4,5,8-trihydroxy-α-tetralone 4-O-β-D-glucopyranoside (4), and (4S)-4,5,8-trihydroxy-α-tetralone 5-O-β-D-glucopyranoside (5) on the basis of spectroscopic analysis and chemical evidence.

New α-Tetralonyl Glucosides from the Fruit of Juglans mandshurica

Four new diarylheptanoids (1-4), along with two known tetralones (5, 6), were isolated from the roots of Juglans mandshurica and their structures were elucidated on the basis of spectroscopic studies.

Four new diarylheptanoids from the roots of Juglans mandshurica.

Diarylheptanoids, natural products with a 1,7-diphenylheptane structural skeleton, are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species They have become of interest in natural product research over the past twenty years because of their remarkable anti-cancer, anti-emetic, estrogenic, anti-microbial and anti-oxidant activity This paper compiles all 307 naturally occurring diarylheptanoids from 46 plants as reported in 137 references with their distributions, physiological activities and 13C-NMR spectral data

https://journals.sagepub.com/doi/pdf/10.1177/1934578X1000501035

Naturally occurring diarylheptanoids.

Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities.

A new (2) and three known diarylheptanoids (1, 3, and 4), along with one known sesquiterpenoid (5), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. Four of these compounds (2-5) exhibited moderate cytotoxicities against human colon carcinoma and human lung carcinoma cell lines with IC(50)'s ranging from 2 to 25 microg/mL.

Seung-Ho Lee

Papers

Cytotoxic Diarylheptanoids from the Roots of Juglans mandshurica