S
Seungil Paik
Researcher at University of British Columbia
Publications - 16
Citations - 846
Seungil Paik is an academic researcher from University of British Columbia. The author has contributed to research in topics: Cellular differentiation & Mesenchymal stem cell. The author has an hindex of 8, co-authored 13 publications receiving 446 citations. Previous affiliations of Seungil Paik include Alberta Children's Hospital & Yonsei University.
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Journal ArticleDOI
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
Lukas F. Mager,Regula Burkhard,Nicola Pett,Noah C. A. Cooke,Kirsty Brown,Hena R. Ramay,Seungil Paik,John Stagg,Ryan A. Groves,Marco Gallo,Ian A. Lewis,Markus B. Geuking,Kathy D. McCoy +12 more
TL;DR: This study isolated three bacterial species—Bifidobacterium pseudolongum, Lactobacillus johnsonii, and Olsenella species—that significantly enhanced efficacy of immune checkpoint inhibitors in four mouse models of cancer, and identifies a previously unknown microbial metabolite immune pathway activated by immunotherapy that may be exploited to develop microbial-based adjuvant therapies.
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Importance of Sox2 in maintenance of cell proliferation and multipotency of mesenchymal stem cells in low-density culture
TL;DR: This study has aimed to repopulate ‘primitive’ cells from late‐passage mesenchymal stem cells (MSCs) of poor multipotentiality and low cell proliferation rate, by simply altering plating density.
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microRNA-495 Inhibits Chondrogenic Differentiation in Human Mesenchymal Stem Cells by Targeting Sox9
TL;DR: In this paper, the 3' untranslated region (3'UTR) of the group-box gene 9 (Sox9) was found to be an important binding site for miR-495.
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miR-449a Regulates the Chondrogenesis of Human Mesenchymal Stem Cells Through Direct Targeting of Lymphoid Enhancer-Binding Factor-1
TL;DR: It is demonstrated that miR-449a directly targets LEF-1, which in turn affects the expression of Sox 9, ultimately leading to the proper regulation of the differentiation and chondrogenesis of human MSCs (hBM-MSCs).
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The effects of COX-2 inhibitor during osteogenic differentiation of bone marrow-derived human mesenchymal stem cells.
TL;DR: The data indicate that the osteogenic potential of MSC is inhibited/delayed by the treatment of high-dose NSAIDs under inflammatory conditions.