S
Sewa S. Legha
Researcher at University of Texas MD Anderson Cancer Center
Publications - 118
Citations - 8123
Sewa S. Legha is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 44, co-authored 118 publications receiving 7939 citations. Previous affiliations of Sewa S. Legha include University of Texas Health Science Center at Houston & University of Texas System.
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Journal ArticleDOI
Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion.
Sewa S. Legha,Robert S. Benjamin,Bruce Mackay,Michael S. Ewer,Sidney Wallace,Manuel Valdivieso,Shelley L. Rasmussen,George R. Blumenschein,Emil J. Freireich +8 more
TL;DR: Cutting peak plasma levels of doxorubicin by continuous infusion reduces cardiotoxicity, and thus lessen cardiac toxicity, in patients treated by standard intravenous injection.
Journal Article
Phase I and Pharmacokinetic Study of ABI-007, a Cremophor-free, Protein-stabilized, Nanoparticle Formulation of Paclitaxel
Nuhad K. Ibrahim,Neil Desai,Sewa S. Legha,Patrick Soon-Shiong,Richard L. Theriault,Edgardo Rivera,Bita Esmaeli,Sigrid Ring,Agop Y. Bedikian,Gabriel N. Hortobagyi,Julie A. Ellerhorst +10 more
TL;DR: ABI-007 offers several features of clinical interest, including rapid infusion rate, absence of requirement for premedication, and a high paclitaxel MTD, which provides support for Phase II trials to determine the antitumor activity of this drug.
Journal ArticleDOI
Tamoxifen in the Treatment of Breast Cancer
TL;DR: A significant increase in the disease-free survival of postmenopausal women treated with tamoxifen is shown, particularly in patients with hormone-receptor-positive tumors.
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Sequential Biochemotherapy Versus Chemotherapy for Metastatic Melanoma: Results From a Phase III Randomized Trial
Omar Eton,Sewa S. Legha,Agop Y. Bedikian,J. Jack Lee,Antonio C. Buzaid,Cynthia Hodges,Sigrid Ring,Nicholas E. Papadopoulos,Carl Plager,Mary Jo East,Feng Zhan,Robert S. Benjamin +11 more
TL;DR: Cytokines substantially augment the antitumor activity of chemotherapy at the expense of considerable toxicity in patients with metastatic melanoma.
Journal ArticleDOI
Treatment of uveal melanoma metastatic to the liver. A review of the M. D. Anderson cancer center experience and prognostic factors
Agop Y. Bedikian,Sewa S. Legha,Giora M. Mavligit,Cesar H. Carrasco,Sunil M. Khorana,Carl Plager,Nicholas Papadopoulos,Robert S. Benjamin +7 more
TL;DR: The results of an institutional experience over the past 2 decades are reviewed and prognostic factors that affect survival from the time the liver metastasis is diagnosed are assessed.