Background: Urinary tract infection (UTI) is one of the most common bacterial illnesses in adults and is one of the most common indications for antibiotics. This study is conducted to determine frequency of E-Coli and its sensitivity to nitrofurantoin in patients with urinary tract infection.
Materials and Methods: The study was conducted at a tertiary care hospital of District Peshawar, i.e. Khyber Teaching Hospital (KTH), after reviewed and approved by the Committee for Ethical Review of Research involving Human Subjects of KTH. Non-random consecutive sampling technique was used for the collection of data and data collection was completed in 06 months’ time i.e. from 20th February to 19th August 2018. The survey was conducted as a descriptive cross-sectional study using open Epi calculator, keeping confidence interval of 95%, sample size calculated is 148. Urine samples were collected in sterile containers and was sent to laboratory for routine examination, culture and sensitivity. A colony 105 or more was considered E Coli growth. Nitrofurantoin was used to check the sensitivity for organisms as per operational definition. All the tests and examinations were carried out under the supervision of experienced medical specialist and microbiologist.
RESULTS: In this study, 148 patients were studied. Average age was 41.86 years + 11.62SD. E coli was found in 91(61.5%) of patients out of total 148 patients. Among UTI patients 78(85.7%) were sensitive to Nitrofurantoin.
CONCLUSION: High prevalence of drug-resistant urinary tract pathogens, particularly to Nitrofurantoin suggests cautious use of antibiotic therapy for the treatment of UTI

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Frequency of E coli and its sensitivity to nitrofurantion in patients with urinary tract infection

Diabetes complications like diabetic (foot ulcer) (DFU) are frequent and may be incapacitating. Patients with diabetes who have anemia have a higher chance of developing DFU. Objectives: To analyze the relationship between anemia and DFU in the patients. Methods: This study was carried out at the department of Medical Unit Khyber Teaching Hospital from 1st March 2022 to 31st March 2023 in Pakistan. Sample size 50 All patients with diabetes and DFU were included. The following demographic, clinical, and laboratory parameters were compared between patients with and without anemia ( age, sex, body mass index) (BMI), type of diabetes, duration of diabetes, glycosylated hemoglobin (HbA1c), and serum ferritin levels. Results: The study comprised 90 participants with both diabetes and DFU. 39 (43.3%) of these individuals had anemia. There was no significant difference in the [mean age] (p=0.664), [sex] (p=0.392),[ BMI] (p=0.532), type of diabetes (p=0.505), duration of diabetes (p=0.084), and HbA1c (p=0.194) between the [anemic and non-anemic] patients. However, the (mean serum ferritin levels) were significantly lower in anemic patients compared with non-anemic patients [p<0.001]. Conclusion: Lower serum ferritin levels are linked to anemia, a prevalent complication in DFU patients. To assess the involvement of anemia in the onset and course of DFU, further research is required. Keywords: Anemia, Diabetic, Foot Ulcer, Department of Medicine, KTH Peshawar, Cross-Sectional Study.

Shah Umam

Papers

Frequency of E coli and its sensitivity to nitrofurantion in patients with urinary tract infection

Analyzing the Relationship Between Anemia and Diabetic (Foot Ulcer) at Department of Medicine KTH Peshawar a Cross-Sectional Study