Frequency of E coli and its sensitivity to nitrofurantion in patients with urinary tract infection

TLDR: High prevalence of drug-resistant urinary tract pathogens, particularly to Nitrofurantoin suggests cautious use of antibiotic therapy for the treatment of UTI.

Abstract: Background: Urinary tract infection (UTI) is one of the most common bacterial illnesses in adults and is one of the most common indications for antibiotics. This study is conducted to determine frequency of E-Coli and its sensitivity to nitrofurantoin in patients with urinary tract infection. Materials and Methods: The study was conducted at a tertiary care hospital of District Peshawar, i.e. Khyber Teaching Hospital (KTH), after reviewed and approved by the Committee for Ethical Review of Research involving Human Subjects of KTH. Non-random consecutive sampling technique was used for the collection of data and data collection was completed in 06 months’ time i.e. from 20th February to 19th August 2018. The survey was conducted as a descriptive cross-sectional study using open Epi calculator, keeping confidence interval of 95%, sample size calculated is 148. Urine samples were collected in sterile containers and was sent to laboratory for routine examination, culture and sensitivity. A colony 105 or more was considered E Coli growth. Nitrofurantoin was used to check the sensitivity for organisms as per operational definition. All the tests and examinations were carried out under the supervision of experienced medical specialist and microbiologist. RESULTS: In this study, 148 patients were studied. Average age was 41.86 years + 11.62SD. E coli was found in 91(61.5%) of patients out of total 148 patients. Among UTI patients 78(85.7%) were sensitive to Nitrofurantoin. CONCLUSION: High prevalence of drug-resistant urinary tract pathogens, particularly to Nitrofurantoin suggests cautious use of antibiotic therapy for the treatment of UTI