S
Shahar Dotan
Researcher at Ben-Gurion University of the Negev
Publications - 32
Citations - 2810
Shahar Dotan is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 17, co-authored 27 publications receiving 2485 citations. Previous affiliations of Shahar Dotan include Weizmann Institute of Science.
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Journal ArticleDOI
The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions.
Ron N. Apte,Shahar Dotan,Moshe Elkabets,Malka R. White,Eli Reich,Yaron Carmi,Xiaping Song,Tatyana Dvozkin,Yakov Krelin,Elena Voronov +9 more
TL;DR: It is proposed that membrane-associated IL-1α expressed on malignant cells stimulates anti-tumor immunity and activates inflammation that promotes invasiveness and also induces tumor-mediated suppression, pointing to its feasibility in cancer therapy.
Journal ArticleDOI
Differential release of chromatin-bound IL-1α discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
Idan Cohen,Peleg Rider,Yaron Carmi,Alex Braiman,Shahar Dotan,Malka R. White,Elena Voronov,Michael U. Martin,Charles A. Dinarello,Ron N. Apte +9 more
TL;DR: It is shown that intracellular IL-1α is a chromatin-associated cytokine and highly dynamic in the nucleus of living cells and nuclear trafficking and differential release during necrosis vs. apoptosis demonstrate that inflammation by IL- 1α is tightly controlled.
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Interleukin-1β–Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen–Induced Tumors
Yakov Krelin,Elena Voronov,Shahar Dotan,Moshe Elkabets,Eli Reich,Mina Fogel,Monika Huszar,Yoichiro Iwakura,Shraga Segal,Charles A. Dinarello,Ron N. Apte +10 more
TL;DR: Fibrosarcoma cell lines, established from 3-MCA-induced tumors from IL-1Ra-deficient mice, were more aggressive and metastatic than lines from WT mice; cell lines fromIL-1- deficient mice were the least invasive.
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Lack of Interleukin-1α or Interleukin-1β Inhibits Transformation of Steatosis to Steatohepatitis and Liver Fibrosis in Hypercholesterolemic Mice
Yehuda Kamari,Aviv Shaish,Einav Vax,Einav Vax,Shay Shemesh,Shay Shemesh,Michal Kandel-Kfir,Yaron Arbel,Sarita Olteanu,Sarita Olteanu,Iris Barshack,Iris Barshack,Shahar Dotan,Elana Voronov,Charles A. Dinarello,Ron N. Apte,Dror Harats,Dror Harats +17 more
TL;DR: These data demonstrate the critical role of IL-1α andIL-1β in the transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice.
Journal ArticleDOI
The Role of Macrophage-Derived IL-1 in Induction and Maintenance of Angiogenesis
Yaron Carmi,Elena Voronov,Shahar Dotan,Nitza Lahat,Michal A. Rahat,Mina Fogel,Monika Huszar,Malka R. White,Charles A. Dinarello,Ron N. Apte +9 more
TL;DR: Targeting IL-1β has the potential to inhibit angiogenesis in pathological situations and may be of considerable clinical value, as shown by the dramatic reduction of inflammatory and angiogenic responses in Matrigel plugs that contained macrophage supernatants from control mice.