S
Shannan R. Tujios
Researcher at University of Texas Southwestern Medical Center
Publications - 25
Citations - 769
Shannan R. Tujios is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Liver transplantation & Medicine. The author has an hindex of 11, co-authored 20 publications receiving 599 citations. Previous affiliations of Shannan R. Tujios include University of Michigan.
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Journal ArticleDOI
Mechanisms of drug-induced liver injury: from bedside to bench
TL;DR: New developments regarding the potential role of reactive metabolites, mitochondrial toxicity, host immune-response pathways and biliary transporters in the etiopathogenesis of DILI are highlighted.
Journal ArticleDOI
Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure.
Filipe S. Cardoso,Michelle Gottfried,Shannan R. Tujios,Jody C. Olson,Constantine J. Karvellas +4 more
TL;DR: In a large cohort of ALF patients, hyperammonemia was associated with high‐grade HE and worse 21‐day TFS, and CRRT wasassociated with a reduction in serum ammonia level and improvement of 21‐ day TFS.
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Risk Factors and Outcomes of Acute Kidney Injury in Patients With Acute Liver Failure
Shannan R. Tujios,Linda S. Hynan,Miguel A. Vazquez,Anne M. Larson,Emmanuel Seremba,Corron Sanders,William M. Lee +6 more
TL;DR: Based on a retrospective analysis of data from more than 1600 patients, AKI is common in patients with ALF and affects short- and long-term outcomes, but patients have better outcomes than those with other forms of ALF.
Journal ArticleDOI
Acute liver failure induced by idiosyncratic reaction to drugs: Challenges in diagnosis and therapy
Shannan R. Tujios,William M. Lee +1 more
TL;DR: DILI that reaches the threshold of ALF will more often than not require transplantation, since survival without transplant is around 25%.
Journal ArticleDOI
Short and Long-Term Outcomes in Patients with Acute Liver Failure Due to Ischemic Hepatitis
Ryan M. Taylor,Shannan R. Tujios,Kartik Jinjuvadia,Timothy Davern,Obaid S. Shaikh,Steve Han,Raymond T. Chung,William M. Lee,Robert J. Fontana +8 more
TL;DR: A higher admission serum phosphate level and more advanced encephalopathy are associated with a lower likelihood of short-term survival of hospitalized patients with ALF due to ischemic hepatitis.