S
Shaodong Guo
Researcher at Texas A&M University
Publications - 83
Citations - 6944
Shaodong Guo is an academic researcher from Texas A&M University. The author has contributed to research in topics: FOXO1 & Insulin resistance. The author has an hindex of 34, co-authored 68 publications receiving 6012 citations. Previous affiliations of Shaodong Guo include Texas A&M Health Science Center & University of Illinois at Chicago.
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Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
TL;DR: FKHR, a human homologue of the DAF16 transcription factor in Caenorhabditis elegans, is rapidly phosphorylated by human protein kinase Bα (PKBα) at Thr-24, Ser-256, and Ser-319 in vitro and at a much faster rate than BAD, which is thought to be a physiological substrate for PKB.
Journal ArticleDOI
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.
TL;DR: These results provide the first report that FK HR stimulates promoter activity through an IRS and that phosphorylation of FKHR by PKB mediates effects of insulin on gene expression, and may provide an evolutionarily conserved mechanism by which insulin and related factors regulate gene expression.
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FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
Wenwei Zhang,Sandip Patil,Sandip Patil,Balwant Chauhan,Balwant Chauhan,Shaodong Guo,Shaodong Guo,David R. Powell,Jamie Le,Jamie Le,Angelos Klotsas,Angelos Klotsas,Ryan Matika,Ryan Matika,Xiangshan Xiao,Xiangshan Xiao,Roberta Franks,Kim A. Heidenreich,Mini P. Sajan,Robert V. Farese,Donna B. Stolz,Patrick Tso,Seung Hoi Koo,Seung Hoi Koo,Marc Montminy,Terry G. Unterman,Terry G. Unterman +26 more
TL;DR: Results indicate that FoxO proteins promote hepatic glucose production through multiple mechanisms and contribute to the regulation of other metabolic pathways important in the adaptation to fasting and feeding in the liver, including glycolysis, the pentose phosphate shunt, and lipogenic and sterol synthetic pathways.
Journal ArticleDOI
Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation
Xiaocheng C. Dong,Kyle D. Copps,Shaodong Guo,Yedan Li,Ramya Kollipara,Ronald A. DePinho,Morris F. White +6 more
TL;DR: It is demonstrated that constitutively active Foxo1 significantly contributes to hyperglycemia during severe hepatic insulin resistance, and that the Irs1/2 --> PI3K --> Akt --> Foxo 1 branch of insulin signaling is largely responsible for hepatic diabetes-regulated glucose homeostasis and somatic growth.
Insulin Signaling, Resistance, and the Metabolic Syndrome: Insights
TL;DR: In this article, the authors discuss the basis of insulin signaling, insulin resistance in different mouse models, and how a deficiency of insulin signalling components in different organs contributes to the features of the metabolic syndrome.