Showing papers by "Shaomin Yan published in 2006"
TL;DR: The current state, history, future, mutation tendency and species susceptibility of influenza A virus proteins are summarized based on probabilistic analyses on amino acid pairs and that of proteins which have been studied in the past are compared.
Abstract: In this review we summarize the current state, history, future, mutation tendency and species susceptibility of influenza A virus proteins based on our probabilistic analyses on amino acid pairs, and compare the current state of influenza A virus proteins with that of proteins which we have studied in the past.
26 citations
TL;DR: The relationship of mutations between 241 H5N1 hemagglutinins of influenza A virus was determined according to their amino acid and RNA codon sequences and the would-be-mutated amino acids were predicted by means of translation probabilities between RNA codons and mutated amino acids.
Abstract: The relationship of mutations between 241 H5N1 hemagglutinins of influenza A virus was determined according to their amino acid and RNA codon sequences. Six probability values were calculated for each amino acid in each hemagglutinin. With these six numeric values as independents and the probability of mutation occurrence as dependent, a logistic regression was used to model 753 point mutations from the 241 hemagglutinins to derive population estimates. Thereafter, the future mutation positions in H5N1 hemagglutinin were predicted. Finally, the would-be-mutated amino acids in H5N1 hemagglutinin were predicted by means of translation probabilities between RNA codons and mutated amino acids.
18 citations
TL;DR: The results demonstrated that mutated amino acids generally follow the direction of the theoretical distributions governed by RNA codons, which highlights the mutation trend of amino acids in hemagglutinins and provides a method for estimating possible mutations in a protein according to its theoretical distributions.
Abstract: In this study, we used the 183 translation probabilities between RNA codons and mutated amino acids to construct the theoretical distributions of mutated amino acids in hemagglutinins of influenza A virus. We then compared the actual distributions of mutated amino acids from 953 hemagglutinins with their theoretical ones. The results demonstrated that mutated amino acids generally follow the direction of the theoretical distributions governed by RNA codons. This, in turn, highlights the mutation trend of amino acids in hemagglutinins and provides a method for estimating possible mutations in a protein according to its theoretical distributions of mutated amino acids.
14 citations