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Sharon E Haynes
Researcher at University of California, San Francisco
Publications - 1
Citations - 1192
Sharon E Haynes is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Microglia & Chemotaxis. The author has an hindex of 1, co-authored 1 publications receiving 1019 citations.
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The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Sharon E Haynes,Gunther Hollopeter,Gunther Hollopeter,Guang Yang,Dana Kurpius,Michael E. Dailey,Wen-Biao Gan,David Julius +7 more
TL;DR: It is shown that microglia from mice lacking Gi-coupled P2Y12 receptors exhibit normal baseline motility but are unable to polarize, migrate or extend processes toward nucleotides in vitro or in vivo, implying that P2 Y12 is a primary site at which nucleotide act to induce microglial chemotaxis at early stages of the response to local CNS injury.