S
Sharon L. Camhi
Researcher at University of Arizona
Publications - 11
Citations - 1163
Sharon L. Camhi is an academic researcher from University of Arizona. The author has contributed to research in topics: Enhancer & Transcription factor. The author has an hindex of 10, co-authored 11 publications receiving 1120 citations. Previous affiliations of Sharon L. Camhi include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation.
TL;DR: It is demonstrated that LPS induces high mRNA levels of the stress-inducible gene heme oxygenase-1 (HO-1) in the rat lung and the molecular regulation of HO-1 gene expression after exposure of RAW 264.7 macrophage cells to LPS is examined.
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Identification of a Second Region Upstream of the Mouse Heme Oxygenase-1 Gene That Functions as a Basal Level and Inducer-dependent Transcription Enhancer
TL;DR: A 161-base pair fragment (AB1) 10 kilobase pairs upstream of the transcription start site of the mouse heme oxygenase-1 gene functions as a basal level and inducer-dependent enhancer and was not significantly affected by any of these chemicals.
Journal Article
The oxidative stress response
TL;DR: This article discusses some of the major aspects of these molecular responses, including alterations in the gene expression of antioxidant enzymes, stress-response genes, and cytokines, and the regulatory mechanisms that control this genetic response are highly complex.
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Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5' distal enhancers: role of reactive oxygen intermediates and AP-1.
TL;DR: Treatment of cells with the antioxidants N-acetyl-L-cysteine (NAC) and dimethyl sulfoxide (DMSO) not only blunts LPS-induced production of ROI, but also significantly attenuates L PS-induced HO-1 messenger RNA (mRNA) expression and gene transcription.
Journal ArticleDOI
AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1
Patty J. Lee,Patty J. Lee,Sharon L. Camhi,Beek Yoke Chin,Jawed Alam,Augustine M.K. Choi,Augustine M.K. Choi +6 more
TL;DR: The data suggest that the 5' distal enhancer elements of the HO-1 gene in concert with the promoter regulate HO- 1 gene induction and highlight the complexity of HO-2 gene transcription in response to hyperoxia.