S
Sharon S. Chen
Researcher at University of California, Los Angeles
Publications - 14
Citations - 2020
Sharon S. Chen is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Phosphorylation & Bottom-up proteomics. The author has an hindex of 11, co-authored 14 publications receiving 1885 citations. Previous affiliations of Sharon S. Chen include University of Washington & Institute for Systems Biology.
Papers
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Journal ArticleDOI
The PeptideAtlas project
Frank Desiere,Eric W. Deutsch,Nichole L. King,Alexey I. Nesvizhskii,Parag Mallick,Jimmy K. Eng,Sharon S. Chen,James S. Eddes,Sandra N. Loevenich,Ruedi Aebersold +9 more
TL;DR: A summary of the process and details about the Human, Drosophila and Yeast PeptideAtlas builds are presented and a uniform statistical validation ensures a consistent and high-quality set of peptide and protein identifications.
Journal ArticleDOI
Computational prediction of proteotypic peptides for quantitative proteomics
Parag Mallick,Markus Schirle,Sharon S. Chen,Mark R. Flory,Hookeun Lee,Hookeun Lee,Daniel Martin,Jeffrey A. Ranish,Brian Raught,Robert Schmitt,Thilo Werner,Bernhard Kuster,Ruedi Aebersold +12 more
TL;DR: Using >600,000 peptide identifications generated by four proteomic platforms, it is shown that characteristic physicochemical properties of these peptides were used to develop a computational tool that can predict proteotypic peptides for any protein from any organism, for a given platform, with >85% cumulative accuracy.
Journal ArticleDOI
Mass spectrometry-based quantitative proteomic profiling.
Wei Yan,Sharon S. Chen +1 more
TL;DR: Developing the technology for targeting sub-proteomes on a functional basis - such as selecting proteins with differential expression profiles from mass spectrometric analyses, for further mass spectroscopic sequencing in an intelligent manner--is expected in the near future.
Journal ArticleDOI
A metaproteomic approach to study human-microbial ecosystems at the mucosal luminal interface.
Xiaoxiao Li,James LeBlanc,Allison K Truong,Ravi Vuthoori,Sharon S. Chen,Jonathan L. Lustgarten,Bennett E. Roth,Jeff Allard,Andrew Ippoliti,Laura L. Presley,James Borneman,William L. Bigbee,Vanathi Gopalakrishnan,Thomas G. Graeber,David Elashoff,Jonathan Braun,Lee Goodglick +16 more
TL;DR: A novel method integrating lavage sampling of the human mucosal surface, high-throughput proteomics, and a unique suite of bioinformatic and statistical analyses resulting in a robust and integrated proteomic approach is developed.
Journal ArticleDOI
Abundance Ratio-Dependent Proteomic Analysis by Mass Spectrometry
Timothy J. Griffin,Chris M. Lock,Xiao jun Li,Alpesh A. Patel,Iryna Chervetsova,Hookeun Lee,Michael E. Wright,Jeffrey A. Ranish,Sharon S. Chen,Sharon S. Chen,Ruedi Aebersold +10 more
TL;DR: A novel approach to quantitative proteomics is described, based on a highly accurate algorithm for the automated quantification of chromatographically fractionated, isotope-coded affinity-tagged peptides and MALDI quadrupole time-of-flight tandem mass spectrometry for their identification.