S
Shasha Xing
Researcher at Huazhong University of Science and Technology
Publications - 11
Citations - 719
Shasha Xing is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Transcytosis & Endothelium. The author has an hindex of 9, co-authored 10 publications receiving 522 citations.
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Journal ArticleDOI
Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway.
Tao Zheng,Xiaoyan Yang,Dan Wu,Shasha Xing,Fang Bian,Wenjing Li,Jiangyang Chi,Xiangli Bai,Guangjie Wu,Xiaoqian Chen,Yonghui Zhang,Si Jin +11 more
TL;DR: The aim of this study was to evaluate the therapeutic effects of salidroside on diabetic mice and to explore the underlying mechanisms.
Journal ArticleDOI
TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ.
You-Zhi Zhang,Xiaoyan Yang,Fang Bian,Pin-Hui Wu,Shasha Xing,Gao Xu,Wenjing Li,Jiangyang Chi,Changhan Ouyang,Tao Zheng,Dan Wu,Yonghui Zhang,Yongsheng Li,Si Jin +13 more
TL;DR: In ApoE(-/-) mice, both NF-κB and PPAR-γ inhibitors alleviated the early atherosclerotic changes promoted by TNF-α and suggest that inhibitors of either NF-σB or PPar-γ can be used to target atherosclerosis.
Journal ArticleDOI
Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.
Tao Zheng,Xiaoyan Yang,Wenjin Li,Qibin Wang,Li Chen,Li Chen,Dan Wu,Fang Bian,Shasha Xing,Si Jin +9 more
TL;DR: It is demonstrated that salidroside protects against NAFLD by improving hepatic lipid metabolism and NLRP3 inflammasome activation, and these actions are related to the regulation of the oxidative stress and AMPK-dependent TXNIP/NLRP3 pathways.
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C‐reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells
Fang Bian,Xiaoyan Yang,Fan Zhou,Pin-Hui Wu,Shasha Xing,Gao Xu,Wenjing Li,Jiangyang Chi,Changhan Ouyang,Yonghui Zhang,Bin Xiong,Yongsheng Li,Tao Zheng,Dan Wu,Xiaoqian Chen,Si Jin +15 more
TL;DR: The effect of CRP on transcytosis of LDL across endothelial cells and the underlying mechanisms are examined to explore the underlying mechanism of atherosclerosis.
Journal ArticleDOI
Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway.
Shasha Xing,Xiaoyan Yang,Tao Zheng,Wenjing Li,Dan Wu,Jiangyang Chi,Fang Bian,Xiangli Bai,Guangjie Wu,You-Zhi Zhang,Cun-tai Zhang,Yonghui Zhang,Yongsheng Li,Si Jin +13 more
TL;DR: The action of SAL to reduce atherosclerotic lesion formation may at least be attributed to its effect on improving endothelial function by promoting nitric oxide production, which was associated with mitochondrial depolarization and subsequent activation of the AMPK/PI3K/Akt/eNOS pathway.