S
Shawn Witham
Researcher at Clemson University
Publications - 14
Citations - 847
Shawn Witham is an academic researcher from Clemson University. The author has contributed to research in topics: Web server & Delphi. The author has an hindex of 10, co-authored 14 publications receiving 713 citations.
Papers
More filters
Journal ArticleDOI
DelPhi: a comprehensive suite for DelPhi software and associated resources
Lin Li,Chuan Li,Subhra Sarkar,Jie Zhang,Shawn Witham,Zhe Zhang,Lin Wang,Nicholas Smith,Marharyta Petukh,Emil Alexov +9 more
TL;DR: A comprehensive suite for the well-known Poisson-Boltzmann solver, Del Phi, enriched with additional features to facilitate DelPhi usage and provides links to third party developed resources either utilizing DelPh i or providing plugins for DelPhI.
Journal ArticleDOI
On the role of electrostatics in protein–protein interactions
TL;DR: It is pointed out that the pH-optimum (pH of optimal binding affinity) varies among the protein-protein complexes, and perhaps is a result of their adaptation to particular subcellular compartments, and the similarities and differences between hetero- and homo-complexes are outlined.
Journal ArticleDOI
An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity
Kyoko Takano,Dan Liu,Patrick S. Tarpey,Esther M. Gallant,Alex Lam,Shawn Witham,Emil Alexov,Alka Chaubey,Roger E. Stevenson,Charles E. Schwartz,Philip G. Board,Angela F. Dulhunty +11 more
TL;DR: Patients appear to suffer from a new channelopathy comprised of ID, seizures and cardiac problems because of enhanced Ca(2+) release through RyRs in neuronal cells and cardiac muscle cells.
Journal ArticleDOI
A missense mutation in CLIC2 associated with intellectual disability is predicted by in silico modeling to affect protein stability and dynamics
TL;DR: Results of in silico modeling, in conjunction with the polymorphism analysis, suggest that p.H101Q may be a disease‐causing mutation, the first one suggested in the CLIC family.
Journal ArticleDOI
DelPhi Web Server: A comprehensive online suite for electrostatic calculations of biological macromolecules and their complexes
TL;DR: A web server is reported, the DelPhi web server, which utilizes Delphi program to calculate electrostatic energies and the corresponding electrostatic potential and ionic distributions, and dielectric map, and the server provides extra services to fix structural defects, as missing atoms in the structural file and allows for generation of missing hydrogen atoms.