S
Sheng-Ru Yang
Researcher at National Chung Cheng University
Publications - 3
Citations - 60
Sheng-Ru Yang is an academic researcher from National Chung Cheng University. The author has contributed to research in topics: DNA damage & Proinflammatory cytokine. The author has an hindex of 3, co-authored 3 publications receiving 47 citations.
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Journal ArticleDOI
Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma.
Wen-Tsai Ji,Sheng-Ru Yang,Jeff Yi-Fu Chen,Ya-Ping Cheng,Ying-Ray Lee,Ming-Ko Chiang,Hau-Ren Chen +6 more
TL;DR: Data have provided a possible mechanism for arecoline‐induced carcinogenesis in subcytolytic doses in vivo and caused DNA damage through ROS, indicating that the reduced levels of p21 and p27 might facilitate G 1/S transition of the cell cycle and subsequently lead to error‐prone DNA replication.
Journal ArticleDOI
Areca nut extract induces pyknotic necrosis in serum-starved oral cells via increasing reactive oxygen species and inhibiting GSK3β: an implication for cytopathic effects in betel quid chewers.
Wen-Tsai Ji,Cheng-I Lee,Jeff Yi-Fu Chen,Ya-Ping Cheng,Sheng-Ru Yang,Jung-Hua Chen,Hau-Ren Chen +6 more
TL;DR: It is discovered that areca nut extract induced production of autophagosome vacuoles in cells cultured with rich medium but induced pyknosis and ballooning, two morphological alterations frequently observed in betel quid chewers, in cells under a serum-free culture condition.
Journal ArticleDOI
Areca nut extracts exert different effects in oral cancer cells depending on serum concentration: A clue to the various oral alterations in betel quid chewers.
Wen-Tsai Ji,Yao-Chi Chuang,Han-Po Chen,Ching-Chih Lee,Jeff Yi-Fu Chen,Sheng-Ru Yang,Jung-Hua Chen,Chun-Jen Wang,Hau-Ren Chen +8 more
TL;DR: It is concluded that in correlation with serum infiltration ANE caused particular effects in oral cells and possibly the various clinicopathological alterations in vivo.