S
Sheng-Xiang Lin
Researcher at Laval University
Publications - 116
Citations - 4684
Sheng-Xiang Lin is an academic researcher from Laval University. The author has contributed to research in topics: Dehydrogenase & Hydroxysteroid dehydrogenase. The author has an hindex of 34, co-authored 113 publications receiving 4481 citations. Previous affiliations of Sheng-Xiang Lin include Case Western Reserve University.
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Journal ArticleDOI
Endocrine and intracrine sources of androgens in women: Inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
Fernand Labrie,Van Luu-The,Claude Labrie,Alain Bélanger,Jacques Simard,Sheng-Xiang Lin,Georges Pelletier +6 more
TL;DR: DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically.
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The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Fernand Labrie,Van Luu-The,Sheng-Xiang Lin,Labrie Claude,Jacques Simard,Roch Breton,Alain Bélanger +6 more
TL;DR: The various types of human 17β-HSD provide each peripheral cell with the necessary mechanisms to control the level of intracellular androgens and/or estrogens, a new area of hormonal control that the authors call intracrinology.
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Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.
Fernand Labrie,Van Luu-The,Sheng-Xiang Lin,Jacques Simard,Claude Labrie,M El-Alfy,Georges Pelletier,Alain Bélanger +7 more
TL;DR: The last and key step in the formation of all estrogens and androgens is catalyzed by members of the family of 17beta-hydroxysteroid dehydrogenases (17 beta-HSDs), which provide each cell with the means of precisely controlling the intracellular concentration of each sex steroid according to local needs.
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Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution
Debashis Ghosh,Vladimir Z. Pletnev,Dao-Wei Zhu,Zdislaw Wawrzak,William L. Duax,Walter Pangborn,Fernand Labrie,Sheng-Xiang Lin +7 more
TL;DR: The structure of the active site provides a rational basis for designing more specific inhibitors of this breast cancer associated enzyme and a model for steroid and cofactor binding as well as for the estrone to estradiol transition state is proposed.
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Theoretical and experimental biology in one—A symposium in honour of Professor Kuo-Chen Chou’s 50th anniversary and Professor Richard Giegé’s 40th anniversary of their scientific careers
Sheng-Xiang Lin,Jacques Lapointe +1 more
TL;DR: It has been a dream that theoretical biology can be extensively applied in experimental biology to accelerate the understanding of the sophiscated movements in living organisms and such contribution has accelerated the development of protein crystallography, stimulating the study of macromolecular structure and function.