Journal ArticleDOI
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Fernand Labrie,Van Luu-The,Sheng-Xiang Lin,Labrie Claude,Jacques Simard,Roch Breton,Alain Bélanger +6 more
TLDR
The various types of human 17β-HSD provide each peripheral cell with the necessary mechanisms to control the level of intracellular androgens and/or estrogens, a new area of hormonal control that the authors call intracrinology.About:
This article is published in Steroids.The article was published on 1997-01-01. It has received 441 citations till now. The article focuses on the topics: 17beta-hydroxysteroid dehydrogenase & Estrone.read more
Citations
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Journal ArticleDOI
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
TL;DR: Understanding steroidogenesis is of fundamental importance to understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiological homeostasis.
Journal ArticleDOI
Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth
R. Bruce Montgomery,Elahe A. Mostaghel,Robert L. Vessella,David L. Hess,Thomas F. Kalhorn,Celestia S. Higano,Lawrence D. True,Peter S. Nelson,Peter S. Nelson +8 more
TL;DR: Maximal therapeutic efficacy in the treatment of castration-resistant prostate cancer will require novel agents capable of inhibiting intracrine steroidogenic pathways within the prostate tumor microenvironment.
Journal ArticleDOI
Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators
TL;DR: This paper summarizes what is known about the biosynthesis of neurosteroids, the enzymes mediating these reactions, their localization during development and in the adult, and their function and mechanisms of action in the developing and adult central and peripheral nervous systems.
Journal ArticleDOI
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.
Trevor M. Penning,Michael E. Burczynski,Joseph M. Jez,Chien Fu Hung,Hseuh-Kung Lin,Haiching Ma,Margaret Moore,Nisha T. Palackal,Kapila Ratnam +8 more
TL;DR: The kinetic parameters, steroid substrate specificity and identities of reaction products were determined for four homogeneous recombinant human 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) isoforms of the aldo-keto reductase (AKR) superfamily and the functional plasticity of these isoforms highlights their ability to modulate the levels of active androgens, oestrogens and progestins.
Journal ArticleDOI
Endocrine and intracrine sources of androgens in women: Inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
Fernand Labrie,Van Luu-The,Claude Labrie,Alain Bélanger,Jacques Simard,Sheng-Xiang Lin,Georges Pelletier +6 more
TL;DR: DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically.
References
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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.
TL;DR: SETOR is designed to exploit the hardware lighting capabilities of the IRIS-4D series graphics workstations to render high-quality raster images of macromolecules that can undergo rotation and translation interactively.
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Important advances in oncology
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Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Wayne M. Geissler,Daphne L. Davis,Ling Wu,Karen D. Bradshaw,S. Patel,Berenice B. Mendonca,Keith O. Elliston,Jean D. Wilson,David W. Russell,Stefan Andersson +9 more
TL;DR: Four substitution and two splice junction mutations were identified in the 17βHSD3 genes of five unrelated male pseudohermaphrodites that severely compromised the activity of the 17 β–HSD type 3 isozyme.
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Allelic loss of chromosomes 16q and 10q in human prostate cancer.
Bob S. Carter,Charles M. Ewing,W S Ward,B F Treiger,T W Aalders,Jack A. Schalken,Jonathan I. Epstein,William B. Isaacs +7 more
TL;DR: The data demonstrate that allelic loss is a common event in prostate cancer and suggest that chromosomes 16q and 10q may contain the sites of tumor suppressor genes important in the pathogenesis of human prostate cancer.
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Characteristics of short-chain alcohol dehydrogenases and related enzymes.
TL;DR: Comparisons of the different enzymes reveal large homologous parts, with clustered similarities indicating regions of special functional/structural importance, and suggest the possibility of related mechanisms and domain properties for different members of the short-chain family.