Showing papers by "Sher Bahadar Khan published in 2006"
TL;DR: The compound 5 can act as a potential lead molecule to develop new drugs for the treatment of hyperpigmentation associated with the high production of melanocytes and the presence of the -CH(2)OH group plays a vital role in the potency of the compounds.
94 citations
TL;DR: Eight new tyrosinase inhibitory cycloartane triterpenoids have been discovered from the methanol extract of the whole plant of Amberboa ramosa (Roxb.) Jafri, which is a member from the Compositae family.
53 citations
Journal Article•
TL;DR: In this article, the n-butanol fraction of the methanolic extract of the whole plant of Amaranthus spinosus Linn was analyzed and the structures of these compounds were determined by spectral analysis (including 1D-and 2D-NMR experiments).
Abstract: Phytochemical investigation of the n-butanol fraction of the methanolic extract of the whole plant ofAmaranthus spinosus Linn. led to the isolation of amaranthoside, a lignan glycoside 1, and amaricin, a coumaroyl adenosine 2 along with stigmasterol glycoside 3. The structures of these compounds were determined by spectral analysis (including 1D-and 2D-NMR experiments) and comparison with literature data.
23 citations
TL;DR: The compounds 1 and perovskoside showed significant inhibitory activity against lipoxygenase and weak to moderate activity against cholinesterases and caffeic acid and ferulic acid have been reported for the first time from Perovskia atriplicifolia.
16 citations
TL;DR: Five daphnane type diterpenes have been isolated from the chloroform soluble fraction of Daphne genkwa and the structure was assigned as 5β‐hydroxyresiniferonol‐6α,7α‐epoxy‐12β‐acetoxy‐9,13,14‐ortho‐2E‐decenoate.
Abstract: Five daphnane type diterpenes have been isolated from the chloroform soluble fraction of Daphne genkwa. The structure of the new compound (1) was assigned as 5β-hydroxyresiniferonol-6α,7α-epoxy-12β-acetoxy-9,13,14-ortho-2E-decenoate by extensive NMR studies. Copyright © 2006 John Wiley & Sons, Ltd.
14 citations
TL;DR: A new flavonol glycoside has been isolated from the ethyl acetate soluble fraction of Amberboa ramosa and assigned the structure 5,7,4′-trihydroxy-3,8-dimethoxylflavone 5-O-β-D-gluco-pyranoside, which displayed weak to moderate inhibition against the xanthine oxidase enzyme.
12 citations
4 citations
TL;DR: Onosmins A (1) and B (2), lipoxygenase inhibitors, have been isolated from Onosma hispida and their structures were established as 2-[(4-methylbenzyl)amino]benzoic acid and methyl 2]-(4methyl benzylamino)benzoate through spectroscopic studies, including 2D-NMR as discussed by the authors.
Abstract: Onosmins A (1) and B (2), lipoxygenase inhibitors, have been isolated from Onosma hispida. Their structures were established as 2-[(4-methylbenzyl)amino]benzoic acid (1) and methyl 2-[(4-methylbenzyl)amino]benzoate (2) through spectroscopic studies, including 2D-NMR. The known compounds apigenin (3), 6,4'-dimethoxy-3,5,7-trihydroxyflavone (4), 6,7-dimethoxy-3,5,4'-trihydroxyflavone (5) and apigenin 7-O-beta-D-glucoside (6) are also reported for the first time from this species. Compounds (1) and (2) inhibited lipoxygenase (LOX, EC 1.13.11.12) enzyme in a concentration-dependent fashion with IC50 values of 24.0 and 36.2 microM, respectively. Lineweaver-Burk as well as Dixon plots and their secondary replots indicated that the nature of inhibition was purely a non-competitive type, with K(i) values 22.0 microM and 31.1, respectively.