Sheridan Gentili

TL;DR: The evidence that such tradeoffs are anticipated from conception and that the periconceptional nutritional environment can programme the developmental trajectory of the stress axis and the systems that maintain and regulate arterial blood pressure is reviewed.

TL;DR: The data reveal an association between toxic concentrations for a number of β-lactam agents and neurotoxic/nephrotoxic effects and clinicians should balance concerns for therapeutic efficacy with potential toxicity when considering aggressive therapy.

TL;DR: It is clear that a better understanding of the relative contributions of the fetal and neonatal nutrient environment to the regulation of key insulin signalling pathways in muscle, visceral adipose tissue and the liver is required to support the development of evidence-based intervention strategies and better outcomes for the IUGR infant.

TL;DR: The impact of fetal nutrition on the biology of the developing adipocyte and brain and the growing evidence base supporting an intergenerational cycle of obesity are discussed.

TL;DR: The consumption of a low concentration fructose beverage is sufficient to cause early signs of the metabolic syndrome in adult rats, and is associated with increased rodent body weight, systolic blood pressure and blood glucose, insulin and triglyceride concentrations in validated rat models.