S
Shi Chang
Researcher at National University of Singapore
Publications - 11
Citations - 1009
Shi Chang is an academic researcher from National University of Singapore. The author has contributed to research in topics: Progenitor cell & Hepatocyte. The author has an hindex of 11, co-authored 11 publications receiving 941 citations. Previous affiliations of Shi Chang include Central South University.
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A novel 3D mammalian cell perfusion-culture system in microfluidic channels
Yi-Chin Toh,Chi Zhang,Jing Zhang,Yuet Mei Khong,Shi Chang,Victor Samper,Danny van Noort,Dietmar W. Hutmacher,Hanry Yu +8 more
TL;DR: A transparent 3D microfluidic channel-based cell culture system that allows cells to be perfusion-cultured in 3D by supporting them with adequate 3D cell-cell and cell-matrix interactions and allows direct optical monitoring of cellular events for a wide range of applications.
Journal ArticleDOI
Nonlinear optical microscopy: use of second harmonic generation and two-photon microscopy for automated quantitative liver fibrosis studies
TL;DR: In this article, the authors used second-harmonic generation (SHG) microscopy and two-photon excited fluorescence (TPEF) images to detect and quantitatively characterize changes in the distribution and amount of collagen and cell morphology.
Journal ArticleDOI
3D hepatocyte monolayer on hybrid RGD/galactose substratum
TL;DR: A hybrid RGD/galactose substratum based on polyethylene terephthalate film conjugated with both RGD peptide and galactose ligand to enhance cell adhesion and functions synergistically to be useful for various applications requiring both effective mass transfer and cellular support.
Nonlinear optical microscopy: use of second harmonic generation and two-photon microscopy for automated quantitative liver fibrosis studies
TL;DR: SHG/TPEF is a sensitive quantitative tool for automated collagen characterization in liver tissue and allows for enhanced detection and quantification of sinusoidal collagen fibers in fibrosis research and clinical diagnostics.
Fibro-C-Index: comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy
Hanry Yu,Peter T. C. So,Jagath C. Rajapakse,Chien-Shing Chen,Huihuan Tang,Shi Chang,Guangfa Xiao,Anju Mythreyi Raja,Chiang Li Wei,Aileen Wee,Chee Leong Cheng,Ser-Mien Chia,Chiang Huen Kang,Shuoyu Xu,Nancy Tan,Dean C. S. Tai +15 more