Shigang Wang

TL;DR: The present review attempts to restate these ultrafiltration circuitries, application methods, end-points, and clinical impacts for pediatric cardiopulmonary bypass procedures.

TL;DR: Next-generation MCS device development should ideally implement designs that offer the benefits of rotary pump technology while providing the physiologic benefits of pulsatile end-organ perfusion.

TL;DR: It is demonstrated that the alternative diagonal pump ECLS circuits appeared to have less systemic inflammatory response and hemolysis compared with the conventional roller pump E CLS circuit in simulated neonatal ECLs systems.

TL;DR: The results show that high flow rates, low perfusate temperature, use of vacuum assisted venous drainage (VAVD), use of roller pump, and pulsatile flow results in higher microemboli counts at postpump site, and hollow fiber membrane oxygenator was able to remove most of the microEmboli, and an opened arterial filter purge line augments the removal of micro Emboli that were not captured by the oxygenator.

TL;DR: The findings suggest that ECG-triggered pulsatile ECLS provides superior end-organ protection with improved renal function and systemic vascular tone.