S
Shigenori Tamaki
Researcher at Mie University
Publications - 19
Citations - 769
Shigenori Tamaki is an academic researcher from Mie University. The author has contributed to research in topics: Cytotoxic T cell & Hepatitis C virus. The author has an hindex of 14, co-authored 19 publications receiving 743 citations.
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Journal ArticleDOI
Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse.
Hiroki Yasui,Esteban C. Gabazza,Shigenori Tamaki,Tetsu Kobayashi,Osamu Hataji,Hisamichi Yuda,Shino Shimizu,Koji Suzuki,Yukihiko Adachi,Osamu Taguchi +9 more
TL;DR: Examination of bronchoalveolar lavage fluid (BALF) concentration of activated PC (APC) and the therapeutic effect of the intratracheal administration of APC on BLM-induced lung fibrosis in mice showed that intratRacheal APC administration inhibits the development of lung Fibrosis in BLM- induced lung injury, giving further support to the important role that the PC pathway plays in the mechanism of lung fibritis.
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Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice
Hisamichi Yuda,Yukihiko Adachi,Osamu Taguchi,Esteban C. Gabazza,Osamu Hataji,Hajime Fujimoto,Shigenori Tamaki,Kimiaki Nishikubo,Kenji Fukudome,Corina N. D’Alessandro-Gabazza,Junko Maruyama,Masahiko Izumizaki,Michiko Iwase,Ikuo Homma,Ryo Inoue,Haruhiko Kamada,Tatsuya Hayashi,Michael Kasper,Bart N. Lambrecht,Peter J. Barnes,Koji Suzuki +20 more
TL;DR: The exogenous supplementation of APC inhibits the immunologic and inflammatory responses induced by Th2 cytokines in a mouse model of asthma and may represent a novel anti-inflammatory treatment.
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Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects.
Keisuke Takeuchi,Yoshinao Kobayashi,Shigenori Tamaki,Tomoaki Ishihara,Yoshihiro Maruo,Jun Araki,Rumi Mifuji,Toshio Itani,Makoto Kuroda,Hiroshi Sato,Masahiko Kaito,Yukihiko Adachi +11 more
TL;DR: The presence of UGT1A1 mutation was investigated in a group of Japanese patients with Crigler–Najjar syndrome type 2 (CNS2) and Gilbert's syndrome, as well as in healthy anicteric subjects.
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Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1.
Shigehito Nakashima,Yusuke Hiraku,Saeko Tada-Oikawa,Terutoshi Hishita,Esteban C. Gabazza,Shigenori Tamaki,Ichiro Imoto,Yukihiko Adachi,Shosuke Kawanishi +8 more
TL;DR: Results suggest that bafilomycin A(1)-induced apoptosis in MKN-1 cells is mediated by other proteases released after lysosomal dysfunction followed by activation of caspase-3 in a cytochrome c-independent manner.
Journal Article
Early diagnosis of hepatocellular carcinoma using a sensitive assay for serum des-gamma-carboxy prothrombin: a prospective study.
Jiro Ikoma,Masahiko Kaito,Tomoaki Ishihara,Naoki Nakagawa,Akira Kamei,Naoki Fujita,Motoh Iwasa,Shigenori Tamaki,Shozo Watanabe,Yukihiko Adachi +9 more
TL;DR: Investigation of the usefulness of measuring des-gamma-carboxy prothrombin by a highly sensitive assay by a sensitive assay combined with alpha-fetoprotein for detecting hepatocellular carcinoma in chronic liver disease patients and for monitoring recurrence after treatment of hepato Cell carcinoma finds it useful.