S
Shikha Saxena
Researcher at Indian Veterinary Research Institute
Publications - 50
Citations - 375
Shikha Saxena is an academic researcher from Indian Veterinary Research Institute. The author has contributed to research in topics: Virus & Apoptosis. The author has an hindex of 11, co-authored 42 publications receiving 299 citations.
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Journal ArticleDOI
Apoptosis induced by NS1 gene of Canine Parvovirus-2 is caspase dependent and p53 independent
Lovleen Saxena,G.V.P.P.S. Ravi Kumar,Shikha Saxena,Uttara Chaturvedi,Aditya Prasad Sahoo,Lakshya Veer Singh,Lakshman Santra,S. K. Palia,G. S. Desai,Ashok K. Tiwari +9 more
TL;DR: Evaluating the apoptotic potential of CPV-2.NS1 in HeLa cells showed the induction of apoptosis to be caspase dependent and p53 independent, and non structural protein 1 (NS1) of many parvoviruses has been found to be apoptotic.
Journal ArticleDOI
Velogenic Newcastle Disease Virus as an Oncolytic Virotherapeutics: In Vitro Characterization
Rajiv Kumar,Ashok K. Tiwari,Uttara Chaturvedi,G.V.P.P.S. Ravi Kumar,Aditya Prasad Sahoo,R. S. Rajmani,Lovleen Saxena,Shikha Saxena,Sangeeta Tiwari,Sudesh Kumar +9 more
TL;DR: Newcastle disease virus (NDV), a poultry virus, is nonpathogenic to human and domestic animals and has a long history of being used in oncotherapy research in several preclinical studies, and its cytotoxic potential was evaluated by observing morphological, biochemical, and nuclear landmarks of apoptosis.
Journal ArticleDOI
Comparative and temporal transcriptome analysis of peste des petits ruminants virus infected goat peripheral blood mononuclear cells
Siddappa Manjunath,Siddappa Manjunath,Bishnu Prasad Mishra,Bina Mishra,Aditya Prasad Sahoo,Ashok K. Tiwari,Kaushal Kishore Rajak,Dhanavelu Muthuchelvan,Shikha Saxena,Lakshman Santra,Amit Ranjan Sahu,Sajad Ahmad Wani,R. P. Singh,Yajuvendra Singh,A. B. Pandey,Sonam Kanchan,R. K. Singh,Gandham Ravi Kumar,Sarath Chandra Janga,Sarath Chandra Janga +19 more
TL;DR: In this paper, the temporal dynamics of immune response in goat peripheral blood mononuclear cells (PBMCs) infected with Sungri/96 vaccine virus was investigated by transcriptome analysis.
Comparative and temporal transcriptome analysis of peste des petits ruminants virus infected goat peripheral blood mononuclear cells
Siddappa Manjunath,Siddappa Manjunath,Bishnu Prasad Mishra,Bina Mishra,Aditya Prasad Sahoo,Ashok K. Tiwari,Kaushal Kishore Rajak,Dhanavelu Muthuchelvan,Shikha Saxena,Lakshman Santra,Amit Ranjan Sahu,Sajad Ahmad Wani,R. P. Singh,Yajuvendra Singh,A. B. Pandey,Sonam Kanchan,R. K. Singh,Gandham Ravi Kumar,Sarath Chandra Janga,Sarath Chandra Janga +19 more
TL;DR: Based on the transcriptome analysis and qRT-PCR validation, an in vitro mechanism for the induction of ISGs by IRFs in an interferon independent manner to trigger a robust immune response was predicted in PPRV infection.
Journal ArticleDOI
Canine Parvovirus Type 2a (CPV-2a)-Induced Apoptosis in MDCK Involves Both Extrinsic and Intrinsic Pathways
Juwar Doley,Lakshya Veer Singh,G.V.P.P.S. Ravi Kumar,Aditya Prasad Sahoo,Lovleen Saxena,Uttara Chaturvedi,Shikha Saxena,Rajiv Kumar,Prafull Kumar Singh,R. S. Rajmani,Lakshman Santra,S. K. Palia,Sangeeta Tiwari,D. R. Harish,Arvind Kumar,G. S. Desai,Smita Gupta,Shishir Kumar Gupta,Ashok K. Tiwari +18 more
TL;DR: The apoptotic potential of the “new CPV-2a” in MDCK cells is evaluated and the mechanism of the induction of apoptosis is elucidated and caspase dependent involving extrinsic, intrinsic, and endoplasmic reticulum pathways.