S
Shilpa A. Joshi
Researcher at Massachusetts Institute of Technology
Publications - 3
Citations - 628
Shilpa A. Joshi is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: AAA proteins & Protein subunit. The author has an hindex of 3, co-authored 3 publications receiving 595 citations.
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Journal ArticleDOI
Sculpting the Proteome with AAA+ Proteases and Disassembly Machines
Robert T. Sauer,Daniel N. Bolon,Briana M. Burton,Randall E. Burton,Julia M. Flynn,Robert A. Grant,Greg L. Hersch,Shilpa A. Joshi,Jon A. Kenniston,Igor Levchenko,Saskia B. Neher,Elizabeth S.C. Oakes,Samia M. Siddiqui,David A. Wah,Tania A. Baker +14 more
TL;DR: Exciting progress has been made in understanding how AAA(+) machines recognize specific proteins as targets and then carry out ATP-dependent dismantling of the tertiary and/or quaternary structure of these molecules during the processes of protein degradation and the disassembly of macromolecular complexes.
Journal ArticleDOI
Communication between ClpX and ClpP during substrate processing and degradation
TL;DR: It is shown that ClpX-ClpP affinity varies with the protein-processing task of Clp X and with the catalytic engagement of the active sites of ClPP.
Journal ArticleDOI
C-terminal domain mutations in ClpX uncouple substrate binding from an engagement step required for unfolding.
TL;DR: Seven mutant enzymes with defective phenotypes of ClpX appear to be defective in a reaction step that engages bound substrate proteins and is required both for enhancement of ATP hydrolysis and for unfolding/disassembly.