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Daniel N. Bolon
Researcher at University of Massachusetts Medical School
Publications - 87
Citations - 4686
Daniel N. Bolon is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Protease & Influenza A virus. The author has an hindex of 34, co-authored 78 publications receiving 4071 citations. Previous affiliations of Daniel N. Bolon include California Institute of Technology & Massachusetts Institute of Technology.
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Sculpting the Proteome with AAA+ Proteases and Disassembly Machines
Robert T. Sauer,Daniel N. Bolon,Briana M. Burton,Randall E. Burton,Julia M. Flynn,Robert A. Grant,Greg L. Hersch,Shilpa A. Joshi,Jon A. Kenniston,Igor Levchenko,Saskia B. Neher,Elizabeth S.C. Oakes,Samia M. Siddiqui,David A. Wah,Tania A. Baker +14 more
TL;DR: Exciting progress has been made in understanding how AAA(+) machines recognize specific proteins as targets and then carry out ATP-dependent dismantling of the tertiary and/or quaternary structure of these molecules during the processes of protein degradation and the disassembly of macromolecular complexes.
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Enzyme-like proteins by computational design
Daniel N. Bolon,Stephen L. Mayo +1 more
TL;DR: The development and initial experimental validation of a computational design procedure aimed at generating enzyme-like protein catalysts called “protozymes” are reported, suggesting a possible mechanism for examining the relationships between protein fold and the evolvability of protein function.
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Experimental illumination of a fitness landscape.
TL;DR: Deep sequencing technology is exploited to experimentally determine the fitness of all possible individual point mutants under controlled conditions for a nine-amino acid region of Hsp90 in yeast, consistent with a nearly neutral model of molecular evolution.
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Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate
TL;DR: The results indicate that core mutations may frequently cause functional defects through subtle disturbances to structure or dynamics in ubiquitin function.
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Asymmetric Interactions of ATP with the AAA+ ClpX6 Unfoldase: Allosteric Control of a Protein Machine
TL;DR: These studies further emphasize commonalities between distant AAA+ family members, including protein and DNA translocases, helicases, motor proteins, clamp loaders, and other ATP-dependent enzymes.