S
Shinichi Kohsaka
Researcher at Keio University
Publications - 198
Citations - 16800
Shinichi Kohsaka is an academic researcher from Keio University. The author has contributed to research in topics: Microglia & Neuroglia. The author has an hindex of 58, co-authored 197 publications receiving 15296 citations.
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Journal ArticleDOI
P2x4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
Makoto Tsuda,Yukari Shigemoto-Mogami,Schuichi Koizumi,Akito Mizokoshi,Shinichi Kohsaka,Michael W. Salter,Kazuhide Inoue +6 more
TL;DR: It is demonstrated that activation of P2X4Rs in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactileAllodynia in normal animals, suggesting that blocking P1X4 receptors in microglial might be a new therapeutic strategy for pain induced by nerve injury.
Journal ArticleDOI
Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals
Hiroaki Wake,Andrew J. Moorhouse,Andrew J. Moorhouse,Shozo Jinno,Shinichi Kohsaka,Junichi Nabekura,Junichi Nabekura +6 more
TL;DR: The results demonstrate that at least part of the dynamic motility of resting microglial processes in vivo is directed toward synapses and propose that microglia vigilantly monitor and respond to the functional status of synapses.
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Microglia-specific localisation of a novel calcium binding protein, Iba1
TL;DR: Results indicated that localisation of Iba1 protein is restricted to microglia both in vitro and in vivo, and that Iba 1 protein plays a role in regulating the function of microglIA, especially in the activated microglial.
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UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
Schuichi Koizumi,Yukari Shigemoto-Mogami,Kaoru Nasu-Tada,Yoichi Shinozaki,Keiko Ohsawa,Makoto Tsuda,Bhalchandra V. Joshi,Kenneth A. Jacobson,Shinichi Kohsaka,Kazuhide Inoue +9 more
TL;DR: The P2Y6 receptor is upregulated when neurons are damaged, and could function as a sensor for phagocytosis by sensing diffusible UDP signals, which is a previously unknown pathophysiological function of P2 receptors in microglia.
Journal ArticleDOI
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors.
Shizuyo Honda,Yo Sasaki,Keiko Ohsawa,Yoshinori Imai,Yasuko Nakamura,Kazuhide Inoue,Shinichi Kohsaka +6 more
TL;DR: Results strongly suggest that membrane ruffling and chemotaxis of microglia induced by ATP or ADP are mediated by Gi/o-coupled P2Y receptors.