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Shiow-Shong Yang
Researcher at Sunovion
Publications - 2
Citations - 118
Shiow-Shong Yang is an academic researcher from Sunovion. The author has contributed to research in topics: Protease & Indinavir. The author has an hindex of 2, co-authored 2 publications receiving 113 citations.
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Journal ArticleDOI
Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease
Nancy M. King,Laurence Melnick,Moses Prabu-Jeyabalan,Ellen A. Nalivaika,Shiow-Shong Yang,Yun Gao,Xiaoyi Nie,Charles M. Zepp,Donald L. Heefner,Celia A. Schiffer +9 more
TL;DR: Structural rearrangements that occur within the protease when it binds to an inhibitor with a single modification must be accounted for in the design of inhibitors with multiple modifications to develop inhibitors that bind sufficiently tightly to drug‐resistant variants of HIV‐1 protease to potentially become the next generation of therapeutic agents.
Journal ArticleDOI
An Escherichia coli Expression Assay and Screen for Human Immunodeficiency Virus Protease Variants with Decreased Susceptibility to Indinavir
TL;DR: The approach described here to be useful for the detection of amino acid substitutions in HIV protease that have been associated with drug resistance as well as for the screening of novel compounds for inhibitory activity.