S
Shipra Sharma
Researcher at International Centre for Genetic Engineering and Biotechnology
Publications - 9
Citations - 205
Shipra Sharma is an academic researcher from International Centre for Genetic Engineering and Biotechnology. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 6, co-authored 9 publications receiving 177 citations.
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Journal ArticleDOI
The nucleoprotein of influenza A virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase RNF43.
TL;DR: This study unravels a novel strategy adopted by IAV for utilizing the much conserved ubiquitin proteasomal pathway and targets RNF43 to modulate p53 ubiquitination levels and hence causes p53 stabilization which is conducive to an enhanced apoptosis level in the host cells.
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Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication.
TL;DR: A proapoptotic role for NP is proposed in IAV pathogenesis, whereby it suppresses expression of antiapoptosis factor API5, thus potentiating the E2F1-dependent apoptotic pathway and ensuring viral replication.
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Influenza A viral nucleoprotein interacts with cytoskeleton scaffolding protein α-actinin-4 for viral replication
Shipra Sharma,Adarsh K. Mayank,Himani Nailwal,Shashank Tripathi,Jenish R. Patel,John B. Bowzard,Pratibha Gaur,Ruben O. Donis,Jacqueline M. Katz,Nancy J. Cox,Renu B. Lal,Humaira Farooqi,Suryaprakash Sambhara,Sunil K. Lal +13 more
TL;DR: The results of the present study indicate that actinin‐4, a novel interacting partner of IAV NP, plays a crucial role in viral replication and this interaction may participate in nuclear localization of NP and/or viral ribonucleoproteins.
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Influenza A Virus Neuraminidase Protein Enhances Cell Survival through Interaction with Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) Protein
Pratibha Gaur,Priya Ranjan,Shipra Sharma,Jenish R. Patel,J. Bradford Bowzard,Shah Kamranur Rahman,Rashmi Kumari,Shivaprakash Gangappa,Jacqueline M. Katz,Nancy J. Cox,Renu B. Lal,Suryaprakash Sambhara,Sunil K. Lal +12 more
TL;DR: A novel role exists for NA in enhancing host cell survival by activating the Src/Akt signaling axis via an interaction with carcinoembryonic antigen-related cell adhesion molecule 6/cluster of differentiation 66c (C6).
Journal Article
Anthropophily of Anophelines in Duars of West Bengal and other regions of India.
TL;DR: Attempts have been made to identify the source of blood meals of twenty three anopheline species from various areas of high malaria endemicity in India and high anthropophily has been closely related to sporozoite infection in anophelines specially in Anopheles minimus and is of great epidemiological significance.